MMP11

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Matrix metallopeptidase 11 (stromelysin 3)
Protein MMP11 PDB 1hv5.png
PDB rendering based on 1hv5.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols MMP11 ; SL-3; ST3; STMY3
External IDs OMIM185261 MGI97008 HomoloGene38116 ChEMBL: 2867 GeneCards: MMP11 Gene
EC number 3.4.24.-
RNA expression pattern
PBB GE MMP11 203878 s at tn.png
PBB GE MMP11 203876 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 4320 17385
Ensembl ENSG00000099953 ENSMUSG00000000901
UniProt P24347 Q02853
RefSeq (mRNA) NM_005940 NM_008606
RefSeq (protein) NP_005931 NP_032632
Location (UCSC) Chr 22:
24.11 – 24.13 Mb
Chr 10:
75.92 – 75.93 Mb
PubMed search [1] [2]

Stromelysin-3 (SL-3) also known as matrix metalloproteinase-11 (MMP-11) is an enzyme that in humans is encoded by the MMP11 gene.[1][2][3][4]

Function[edit]

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the enzyme encoded by this gene is activated intracellularly by furin within the constitutive secretory pathway. Also in contrast to other MMP's, this enzyme cleaves alpha 1-proteinase inhibitor but weakly degrades structural proteins of the extracellular matrix.[4]

References[edit]

  1. ^ Levy A, Zucman J, Delattre O, Mattei MG, Rio MC, Basset P (Aug 1992). "Assignment of the human stromelysin 3 (STMY3) gene to the q11.2 region of chromosome 22". Genomics 13 (3): 881–3. doi:10.1016/0888-7543(92)90175-R. PMID 1639418. 
  2. ^ Anglard P, Melot T, Guerin E, Thomas G, Basset P (Oct 1995). "Structure and promoter characterization of the human stromelysin-3 gene". J Biol Chem 270 (35): 20337–44. doi:10.1074/jbc.270.35.20337. PMID 7657606. 
  3. ^ Luo D, Mari B, Stoll I, Anglard P (Jul 2002). "Alternative splicing and promoter usage generates an intracellular stromelysin 3 isoform directly translated as an active matrix metalloproteinase". J Biol Chem 277 (28): 25527–36. doi:10.1074/jbc.M202494200. PMID 12006591. 
  4. ^ a b "Entrez Gene: MMP11 matrix metallopeptidase 11 (stromelysin 3)". 

Further reading[edit]