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Matrix metallopeptidase 15 (membrane-inserted)
Symbols MMP15 ; MT2-MMP; MTMMP2; SMCP-2
External IDs OMIM602261 MGI109320 HomoloGene20549 IUPHAR: 1639 ChEMBL: 2963 GeneCards: MMP15 Gene
EC number 3.4.24.-
Species Human Mouse
Entrez 4324 17388
Ensembl ENSG00000102996 ENSMUSG00000031790
UniProt P51511 O54732
RefSeq (mRNA) NM_002428 NM_008609
RefSeq (protein) NP_002419 NP_032635
Location (UCSC) Chr 16:
58.06 – 58.08 Mb
Chr 8:
95.35 – 95.37 Mb
PubMed search [1] [2]

Matrix metalloproteinase 15 also known as MMP15 is an enzyme that in humans is encoded by the MMP15 gene.[1][2]


Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proenzymes which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily; members of this subfamily can be anchored to the extracellular membrane by either a transmembrane domain or glycophosphatidylinositol linkage, suggesting that these proteins are expressed at the cell surface rather than secreted in a soluble form.[3]


  1. ^ Sato H, Tanaka M, Takino T, Inoue M, Seiki M (February 1997). "Assignment of the human genes for membrane-type-1, -2, and -3 matrix metalloproteinases (MMP14, MMP15, and MMP16) to 14q12.2, 16q12.2-q21, and 8q21, respectively, by in situ hybridization". Genomics 39 (3): 412–3. doi:10.1006/geno.1996.4496. PMID 9119382. 
  2. ^ Mattei MG, Roeckel N, Olsen BR, Apte SS (February 1997). "Genes of the membrane-type matrix metalloproteinase (MT-MMP) gene family, MMP14, MMP15, and MMP16, localize to human chromosomes 14, 16, and 8, respectively". Genomics 40 (1): 168–9. doi:10.1006/geno.1996.4559. PMID 9070935. 
  3. ^ "Entrez Gene: MMP15". 

Further reading[edit]

External links[edit]

  • The MEROPS online database for peptidases and their inhibitors: M10.015

This article incorporates text from the United States National Library of Medicine, which is in the public domain.