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Matrix metallopeptidase 16 (membrane-inserted)
Protein MMP16 PDB 1rm8.png
PDB rendering based on 1rm8.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols MMP16 ; C8orf57; MMP-X2; MT-MMP2; MT-MMP3; MT3-MMP
External IDs OMIM602262 MGI1276107 HomoloGene55939 IUPHAR: 1640 ChEMBL: 2200 GeneCards: MMP16 Gene
EC number 3.4.24.-
RNA expression pattern
PBB GE MMP16 208166 at tn.png
PBB GE MMP16 208167 s at tn.png
PBB GE MMP16 207012 at tn.png
More reference expression data
Species Human Mouse
Entrez 4325 17389
Ensembl ENSG00000156103 ENSMUSG00000028226
UniProt P51512 Q9WTR0
RefSeq (mRNA) NM_005941 NM_019724
RefSeq (protein) NP_005932 NP_062698
Location (UCSC) Chr 8:
89.04 – 89.34 Mb
Chr 4:
17.85 – 18.12 Mb
PubMed search [1] [2]

Matrix metalloproteinase-16 is an enzyme that in humans is encoded by the MMP16 gene.[1][2]

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene produces at least two transcripts, one which encodes a membrane-bound form and another a soluble form of the protein. Both forms of the protein activate MMP2 by cleavage. This gene was once referred to as MT-MMP2, but was renamed as MT-MMP3 or MMP16.[2]


  1. ^ Takino T, Sato H, Shinagawa A, Seiki M (Nov 1995). "Identification of the second membrane-type matrix metalloproteinase (MT-MMP-2) gene from a human placenta cDNA library. MT-MMPs form a unique membrane-type subclass in the MMP family". J Biol Chem 270 (39): 23013–20. doi:10.1074/jbc.270.39.23013. PMID 7559440. 
  2. ^ a b "Entrez Gene: MMP16 matrix metallopeptidase 16 (membrane-inserted)". 

Further reading[edit]

External links[edit]

  • The MEROPS online database for peptidases and their inhibitors: M10.016