MMP19

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Matrix metallopeptidase 19
Identifiers
Symbols MMP19 ; MMP18; RASI-1
External IDs OMIM601807 MGI1927899 HomoloGene1820 GeneCards: MMP19 Gene
EC number 3.4.24.-
Orthologs
Species Human Mouse
Entrez 4327 58223
Ensembl ENSG00000123342 ENSMUSG00000025355
UniProt Q99542 Q9JHI0
RefSeq (mRNA) NM_001032360 NM_001164197
RefSeq (protein) NP_001259030 NP_001157669
Location (UCSC) Chr 12:
56.23 – 56.24 Mb
Chr 10:
128.79 – 128.8 Mb
PubMed search [1] [2]

Matrix metalloproteinase-19 (MMP-19) also known as matrix metalloproteinase RASI is an enzyme that in humans is encoded by the MMP19 gene.[1][2]

Function[edit]

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This protein is expressed in human epidermis and endothelial cells and it has a role in cellular proliferation, migration, angiogenesis and adhesion. Multiple transcript variants encoding distinct isoforms have been identified for this gene.[2]

References[edit]

  1. ^ Kolb C, Mauch S, Peter HH, Krawinkel U, Sedlacek R (Oct 1997). "The matrix metalloproteinase RASI-1 is expressed in synovial blood vessels of a rheumatoid arthritis patient". Immunol Lett 57 (1–3): 83–8. doi:10.1016/S0165-2478(97)00057-6. PMID 9232430. 
  2. ^ a b "Entrez Gene: MMP19 matrix metallopeptidase 19". 

Further reading[edit]

External links[edit]

  • The MEROPS online database for peptidases and their inhibitors: M10.021