MMP24

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Matrix metallopeptidase 24 (membrane-inserted)
Identifiers
Symbols MMP24 ; MMP-24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP; MT5MMP; MTMMP5
External IDs OMIM604871 MGI1341867 HomoloGene21331 ChEMBL: 5050 GeneCards: MMP24 Gene
RNA expression pattern
PBB GE MMP24 208387 s at tn.png
PBB GE MMP24 213171 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 10893 17391
Ensembl ENSG00000125966 ENSMUSG00000027612
UniProt Q9Y5R2 Q9R0S2
RefSeq (mRNA) NM_006690 NM_010808
RefSeq (protein) NP_006681 NP_034938
Location (UCSC) Chr 20:
33.81 – 33.86 Mb
Chr 2:
155.78 – 155.82 Mb
PubMed search [1] [2]

Matrix metalloproteinase-24 is an enzyme that in humans is encoded by the MMP24 gene.[1][2]

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. This protein activates MMP2 by cleavage. The gene has previously been referred to as MMP25 but has been renamed MMP24.[2]

References[edit]

  1. ^ Llano E, Pendas AM, Freije JP, Nakano A, Knauper V, Murphy G, Lopez-Otin C (Jun 1999). "Identification and characterization of human MT5-MMP, a new membrane-bound activator of progelatinase a overexpressed in brain tumors". Cancer Res 59 (11): 2570–6. PMID 10363975. 
  2. ^ a b "Entrez Gene: MMP24 matrix metallopeptidase 24 (membrane-inserted)". 

Further reading[edit]

  • Nagase H, Woessner JF (1999). "Matrix metalloproteinases.". J. Biol. Chem. 274 (31): 21491–4. doi:10.1074/jbc.274.31.21491. PMID 10419448. 
  • Kinoh H, Hayashita H, Kajita M, et al. (2000). "Assignment of the genes for membrane-type-4 matrix metalloproteinase (Mmp17, MMP17) to mouse chromosome 5, human chromosome band 12q24.3 and membrane-type-5 matrix metalloproteinase (Mmp24, MMP24) to mouse chromosome 2 and human chromosome band 20q11.2→q12, respectively, by radiation hybrid and in situ hybridization.". Cytogenet. Cell Genet. 87 (1-2): 97–8. doi:10.1159/000015402. PMID 10640822. 
  • Romanic AM, Burns-Kurtis CL, Ao Z, et al. (2001). "Upregulated expression of human membrane type-5 matrix metalloproteinase in kidneys from diabetic patients.". Am. J. Physiol. Renal Physiol. 281 (2): F309–17. PMID 11457723. 
  • Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20.". Nature 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
  • Jung M, Römer A, Keyszer G, et al. (2003). "mRNA expression of the five membrane-type matrix metalloproteinases MT1-MT5 in human prostatic cell lines and their down-regulation in human malignant prostatic tissue.". Prostate 55 (2): 89–98. doi:10.1002/pros.10194. PMID 12661033. 
  • Takino T, Koshikawa N, Miyamori H, et al. (2003). "Cleavage of metastasis suppressor gene product KiSS-1 protein/metastin by matrix metalloproteinases.". Oncogene 22 (30): 4617–26. doi:10.1038/sj.onc.1206542. PMID 12879005. 
  • Wang P, Wang X, Pei D (2004). "Mint-3 regulates the retrieval of the internalized membrane-type matrix metalloproteinase, MT5-MMP, to the plasma membrane by binding to its carboxyl end motif EWV.". J. Biol. Chem. 279 (19): 20461–70. doi:10.1074/jbc.M400264200. PMID 14990567. 
  • Gaetje R, Holtrich U, Engels K, et al. (2008). "Expression of membrane-type 5 matrix metalloproteinase in human endometrium and endometriosis.". Gynecol. Endocrinol. 23 (10): 567–73. doi:10.1080/09513590701556921. PMID 17952761.