MMP25

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Matrix metallopeptidase 25
Identifiers
Symbols MMP25 ; MMP-25; MMP20; MMP20A; MMPL1; MT-MMP 6; MT-MMP6; MT6-MMP; MT6MMP; MTMMP6
External IDs OMIM608482 MGI2443938 HomoloGene23375 ChEMBL: 1795103 GeneCards: MMP25 Gene
EC number 3.4.24.-
RNA expression pattern
PBB GE MMP25 207289 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 64386 240047
Ensembl ENSG00000008516 ENSMUSG00000023903
UniProt Q9NPA2 Q3U435
RefSeq (mRNA) NM_004142 NM_001033339
RefSeq (protein) NP_071913 NP_001028511
Location (UCSC) Chr 16:
3.1 – 3.11 Mb
Chr 17:
23.63 – 23.65 Mb
PubMed search [1] [2]

Matrix metalloproteinase-25 is an enzyme that in humans is encoded by the MMP25 gene.[1][2][3]

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily, attached to the plasma membrane via a glycosylphosphatidyl inositol anchor. In response to bacterial infection or inflammation, the encoded protein is thought to inactivate alpha-1 proteinase inhibitor, a major tissue protectant against proteolytic enzymes released by activated neutrophils, facilitating the transendothelial migration of neutrophils to inflammatory sites. The encoded protein may also play a role in tumor invasion and metastasis through activation of MMP2. The gene has previously been referred to as MMP20 but has been renamed MMP25.[3]

References[edit]

  1. ^ Pei D (Feb 2000). "Leukolysin/MMP25/MT6-MMP: a novel matrix metalloproteinase specifically expressed in the leukocyte lineage". Cell Res 9 (4): 291–303. doi:10.1038/sj.cr.7290028. PMID 10628838. 
  2. ^ Velasco G, Cal S, Merlos-Suarez A, Ferrando AA, Alvarez S, Nakano A, Arribas J, Lopez-Otin C (Mar 2000). "Human MT6-matrix metalloproteinase: identification, progelatinase A activation, and expression in brain tumors". Cancer Res 60 (4): 877–82. PMID 10706098. 
  3. ^ a b "Entrez Gene: MMP25 matrix metallopeptidase 25". 

Further reading[edit]

External links[edit]

  • The MEROPS online database for peptidases and their inhibitors: M10.024