MMP28

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Matrix metallopeptidase 28
Identifiers
Symbols MMP28 ; EPILYSIN; MM28; MMP-25; MMP-28; MMP25
External IDs OMIM608417 MGI2153062 HomoloGene41559 ChEMBL: 4870 GeneCards: MMP28 Gene
EC number 3.4.24.-
RNA expression pattern
PBB GE MMP28 219909 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 79148 118453
Ensembl ENSG00000129270 ENSMUSG00000020682
UniProt Q9H239 Q5SSG2
RefSeq (mRNA) NM_001032278 NM_080453
RefSeq (protein) NP_001027449 NP_536701
Location (UCSC) Chr 17:
34.08 – 34.12 Mb
Chr 11:
83.44 – 83.46 Mb
PubMed search [1] [2]

Matrix metalloproteinase 28 also known as epilysin is an enzyme that in humans is encoded by the MMP28 gene.[1][2][3]

Function[edit]

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix for both normal physiological processes, such as embryonic development, reproduction and tissue remodeling, and disease processes, such as asthma and metastasis. This gene encodes a secreted enzyme that degrades casein. Its expression pattern suggests that it plays a role in tissue homeostasis and in wound repair. Transcript variants encoding different isoforms have been described.[3]

References[edit]

  1. ^ Lohi J, Wilson CL, Roby JD, Parks WC (Mar 2001). "Epilysin, a novel human matrix metalloproteinase (MMP-28) expressed in testis and keratinocytes and in response to injury". J Biol Chem 276 (13): 10134–44. doi:10.1074/jbc.M001599200. PMID 11121398. 
  2. ^ Marchenko GN, Strongin AY (Mar 2001). "MMP-28, a new human matrix metalloproteinase with an unusual cysteine-switch sequence is widely expressed in tumors". Gene 265 (1–2): 87–93. doi:10.1016/S0378-1119(01)00360-2. PMID 11255011. 
  3. ^ a b "Entrez Gene: MMP28 matrix metallopeptidase 28". 

Further reading[edit]

External links[edit]

  • The MEROPS online database for peptidases and their inhibitors: M10.030