MMP8

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Matrix metallopeptidase 8 (neutrophil collagenase)
Protein MMP8 PDB 1a85.png
PDB rendering based on 1a85.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols MMP8 ; CLG1; HNC; MMP-8; PMNL-CL
External IDs OMIM120355 MGI1202395 HomoloGene22482 ChEMBL: 4588 GeneCards: MMP8 Gene
EC number 3.4.24.34
RNA expression pattern
PBB GE MMP8 207329 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 4317 17394
Ensembl ENSG00000118113 ENSMUSG00000005800
UniProt P22894 O70138
RefSeq (mRNA) NM_002424 NM_008611
RefSeq (protein) NP_002415 NP_032637
Location (UCSC) Chr 11:
102.58 – 102.6 Mb
Chr 9:
7.56 – 7.57 Mb
PubMed search [1] [2]

Neutrophil collagenase, also known as matrix metalloproteinase-8 (MMP-8) or PMNL collagenase (MNL-CL), is a collagen cleaving enzyme which is present in the connective tissue of most mammals.[1] In humans, the MMP-8 protein is encoded by the MMP8 gene.[2][3]

Function[edit]

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the enzyme encoded by this gene is stored in secondary granules within neutrophils and is activated by autolytic cleavage. Its function is degradation of type I, II and III collagens. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3.[1]

References[edit]

  1. ^ a b "Entrez Gene: MMP8 matrix metallopeptidase 8 (neutrophil collagenase)". 
  2. ^ Hasty KA, Pourmotabbed TF, Goldberg GI, Thompson JP, Spinella DG, Stevens RM, Mainardi CL (July 1990). "Human neutrophil collagenase. A distinct gene product with homology to other matrix metalloproteinases". J. Biol. Chem. 265 (20): 11421–4. PMID 2164002. 
  3. ^ Devarajan P, Mookhtiar K, Van Wart H, Berliner N (June 1991). "Structure and expression of the cDNA encoding human neutrophil collagenase". Blood 77 (12): 2731–8. PMID 1646048. 

Further reading[edit]

External links[edit]

  • The MEROPS online database for peptidases and their inhibitors: M10.002