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MNAT CDK-activating kinase assembly factor 1
Protein MNAT1 PDB 1g25.png
PDB rendering based on 1g25.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols MNAT1 ; CAP35; MAT1; RNF66; TFB3
External IDs OMIM602659 MGI106207 HomoloGene1821 ChEMBL: 5053 GeneCards: MNAT1 Gene
RNA expression pattern
PBB GE MNAT1 203565 s at tn.png
More reference expression data
Species Human Mouse
Entrez 4331 17420
Ensembl ENSG00000020426 ENSMUSG00000021103
UniProt P51948 P51949
RefSeq (mRNA) NM_001177963 NM_008612
RefSeq (protein) NP_001171434 NP_032638
Location (UCSC) Chr 14:
61.2 – 61.44 Mb
Chr 12:
73.12 – 73.27 Mb
PubMed search [1] [2]

CDK-activating kinase assembly factor MAT1 is an enzyme that in humans is encoded by the MNAT1 gene.[1]


Cyclin-dependent kinases (CDKs), which play an essential role in cell cycle control of eukaryotic cells, are phosphorylated and thus activated by the CDK-activating kinase (CAK). CAK is a multisubunit protein that includes CDK7 (MIM 601955), cyclin H (CCNH; MIM 601953), and MAT1. MAT1 (for 'menage a trois-1') is involved in the assembly of the CAK complex.[supplied by OMIM][2]


MNAT1 has been shown to interact with:


  1. ^ Eki T, Okumura K, Abe M, Kagotani K, Taguchi H, Murakami Y et al. (April 1998). "Mapping of the human genes encoding cyclin H (CCNH) and the CDK-activating kinase (CAK) assembly factor MAT1 (MNAT1) to chromosome bands 5q13.3-q14 and 14q23, respectively". Genomics 47 (1): 115–20. doi:10.1006/geno.1997.5053. PMID 9465303. 
  2. ^ "Entrez Gene: MNAT1 menage a trois homolog 1, cyclin H assembly factor (Xenopus laevis)". 
  3. ^ a b c d Talukder AH, Mishra SK, Mandal M, Balasenthil S, Mehta S, Sahin AA et al. (March 2003). "MTA1 interacts with MAT1, a cyclin-dependent kinase-activating kinase complex ring finger factor, and regulates estrogen receptor transactivation functions". J. Biol. Chem. 278 (13): 11676–85. doi:10.1074/jbc.M209570200. PMID 12527756. 
  4. ^ Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931. 
  5. ^ Yee A, Nichols MA, Wu L, Hall FL, Kobayashi R, Xiong Y (December 1995). "Molecular cloning of CDK7-associated human MAT1, a cyclin-dependent kinase-activating kinase (CAK) assembly factor". Cancer Res. 55 (24): 6058–62. PMID 8521393. 
  6. ^ Wang Y, Xu F, Hall FL (October 2000). "The MAT1 cyclin-dependent kinase-activating kinase (CAK) assembly/targeting factor interacts physically with the MCM7 DNA licensing factor". FEBS Lett. 484 (1): 17–21. doi:10.1016/s0014-5793(00)02117-7. PMID 11056214. 
  7. ^ Ko LJ, Shieh SY, Chen X, Jayaraman L, Tamai K, Taya Y et al. (December 1997). "p53 is phosphorylated by CDK7-cyclin H in a p36MAT1-dependent manner". Mol. Cell. Biol. 17 (12): 7220–9. PMC 232579. PMID 9372954. 
  8. ^ Inamoto S, Segil N, Pan ZQ, Kimura M, Roeder RG (November 1997). "The cyclin-dependent kinase-activating kinase (CAK) assembly factor, MAT1, targets and enhances CAK activity on the POU domains of octamer transcription factors". J. Biol. Chem. 272 (47): 29852–8. doi:10.1074/jbc.272.47.29852. PMID 9368058. 

Further reading[edit]