MNDA

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Myeloid cell nuclear differentiation antigen
Protein MNDA PDB 2dbg.png
PDB rendering based on 2dbg.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols MNDA ; PYHIN3
External IDs OMIM159553 HomoloGene74438 GeneCards: MNDA Gene
RNA expression pattern
PBB GE MNDA 204959 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 4332 n/a
Ensembl ENSG00000163563 n/a
UniProt P41218 n/a
RefSeq (mRNA) NM_002432 n/a
RefSeq (protein) NP_002423 n/a
Location (UCSC) Chr 1:
158.8 – 158.82 Mb
n/a
PubMed search [1] n/a

Myeloid cell nuclear differentiation antigen is a protein that in humans is encoded by the MNDA gene.[1][2][3]

The myeloid cell nuclear differentiation antigen (MNDA) is detected only in nuclei of cells of the granulocyte-monocyte lineage. A 200-amino acid region of human MNDA is strikingly similar to a region in the proteins encoded by a family of interferon-inducible mouse genes, designated Ifi-201, Ifi202, and Ifi-203, that are not regulated in a cell- or tissue-specific fashion. The 1.8-kb MNDA mRNA, which contains an interferon-stimulated response element in the 5' UTR, was significantly upregulated in human monocytes exposed to interferon alpha. MNDA is located within 2,200 kb of FCER1A, APCS, CRP, and SPTA1. In its pattern of expression and/or regulation, MNDA resembles IFI16, suggesting that these genes participate in blood cell-specific responses to interferons.[3]

References[edit]

  1. ^ Briggs JA, Burrus GR, Stickney BD, Briggs RC (Sep 1992). "Cloning and expression of the human myeloid cell nuclear differentiation antigen: regulation by interferon alpha". J Cell Biochem 49 (1): 82–92. doi:10.1002/jcb.240490114. PMID 1644857. 
  2. ^ Briggs RC, Briggs JA, Ozer J, Sealy L, Dworkin LL, Kingsmore SF, Seldin MF, Kaur GP, Athwal RS, Dessypris EN (May 1994). "The human myeloid cell nuclear differentiation antigen gene is one of at least two related interferon-inducible genes located on chromosome 1q that are expressed specifically in hematopoietic cells". Blood 83 (8): 2153–62. PMID 7512843. 
  3. ^ a b "Entrez Gene: MNDA myeloid cell nuclear differentiation antigen". 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.