MNT (gene)

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MNT, MAX dimerization protein
Identifiers
Symbols MNT ; MAD6; MXD6; ROX; bHLHd3
External IDs OMIM603039 MGI109150 HomoloGene7842 GeneCards: MNT Gene
RNA expression pattern
PBB GE MNT 204206 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 4335 17428
Ensembl ENSG00000070444 ENSMUSG00000000282
UniProt Q99583 O08789
RefSeq (mRNA) NM_020310 NM_010813
RefSeq (protein) NP_064706 NP_034943
Location (UCSC) Chr 17:
2.29 – 2.3 Mb
Chr 11:
74.83 – 74.85 Mb
PubMed search [1] [2]

Max-binding protein MNT is a protein that in humans is encoded by the MNT gene.[1][2]

The Myc/Max/Mad network comprises a group of transcription factors that co-interact to regulate gene-specific transcriptional activation or repression. This gene encodes a protein member of the Myc/Max/Mad network. This protein has a basic-Helix-Loop-Helix-zipper domain (bHLHzip) with which it binds the canonical DNA sequence CANNTG, known as the E box, following heterodimerization with Max proteins. This protein is likely a transcriptional repressor and an antagonist of Myc-dependent transcriptional activation and cell growth. This protein represses transcription by binding to DNA binding proteins at its N-terminal Sin3-interaction domain.[2]

Interactions[edit]

MNT (gene) has been shown to interact with MLX,[3][4] SIN3A[5] and MAX.[5]

References[edit]

  1. ^ Lo Nigro C, Venesio T, Reymond A, Meroni G, Alberici P, Cainarca S, Enrico F, Stack M, Ledbetter DH, Liscia DS, Ballabio A, Carrozzo R (August 1998). "The human ROX gene: genomic structure and mutation analysis in human breast tumors". Genomics 49 (2): 275–282. doi:10.1006/geno.1998.5241. PMID 9598315. 
  2. ^ a b "Entrez Gene: MNT MAX binding protein". 
  3. ^ Cairo, S; Merla G, Urbinati F, Ballabio A, Reymond A (March 2001). "WBSCR14, a gene mapping to the Williams--Beuren syndrome deleted region, is a new member of the Mlx transcription factor network". Hum. Mol. Genet. (England) 10 (6): 617–627. doi:10.1093/hmg/10.6.617. ISSN 0964-6906. PMID 11230181. 
  4. ^ Meroni, G; Cairo S, Merla G, Messali S, Brent R, Ballabio A, Reymond A (July 2000). "Mlx, a new Max-like bHLHZip family member: the center stage of a novel transcription factors regulatory pathway?". Oncogene (ENGLAND) 19 (29): 3266–3277. doi:10.1038/sj.onc.1203634. ISSN 0950-9232. PMID 10918583. 
  5. ^ a b Meroni, G; Reymond A, Alcalay M, Borsani G, Tanigami A, Tonlorenzi R, Lo Nigro C, Messali S, Zollo M, Ledbetter D H, Brent R, Ballabio A, Carrozzo R (May 1997). "Rox, a novel bHLHZip protein expressed in quiescent cells that heterodimerizes with Max, binds a non-canonical E box and acts as a transcriptional repressor". EMBO J. (ENGLAND) 16 (10): 2892–2906. doi:10.1093/emboj/16.10.2892. ISSN 0261-4189. PMC 1169897. PMID 9184233. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.