From Wikipedia, the free encyclopedia
Jump to: navigation, search
Molybdenum cofactor synthesis 3
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols MOCS3 ; UBA4
External IDs OMIM609277 MGI1916622 HomoloGene6108 GeneCards: MOCS3 Gene
EC number,
RNA expression pattern
PBB GE MOCS3 206141 at tn.png
More reference expression data
Species Human Mouse
Entrez 27304 69372
Ensembl ENSG00000124217 ENSMUSG00000074576
UniProt O95396 A2BDX3
RefSeq (mRNA) NM_014484 NM_001160330
RefSeq (protein) NP_055299 NP_001153802
Location (UCSC) Chr 20:
49.58 – 49.58 Mb
Chr 2:
168.23 – 168.23 Mb
PubMed search [1] [2]

Adenylyltransferase and sulfurtransferase MOCS3 is an enzyme that in humans is encoded by the MOCS3 gene.[1][2]

Molybdenum cofactor (MoCo) is necessary for the function of all molybdoenzymes. One of the enzymes required for the biosynthesis of MoCo is molybdopterin synthase (MPT synthase). The protein encoded by this gene adenylates and activates MPT synthase. This gene contains no introns. A pseudogene of this gene is present on chromosome 14.[2]


  1. ^ Matthies A, Nimtz M, Leimkuhler S (May 2005). "Molybdenum cofactor biosynthesis in humans: identification of a persulfide group in the rhodanese-like domain of MOCS3 by mass spectrometry". Biochemistry 44 (21): 7912–20. doi:10.1021/bi0503448. PMID 15910006. 
  2. ^ a b "Entrez Gene: MOCS3 molybdenum cofactor synthesis 3". 

Further reading[edit]