MOS (gene)

V-mos Moloney murine sarcoma viral oncogene homolog
Identifiers
Symbols	MOS; MGC119962; MGC119963; MSV
External IDs	OMIM: 190060 MGI: 97052 HomoloGene: 3919 GeneCards: MOS Gene
EC number	2.7.11.1
Gene Ontology Molecular function • nucleotide binding • protein serine/threonine kinase activity • protein binding • ATP binding Biological process • regulation of progression through cell cycle • protein amino acid phosphorylation Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4342	17451
Ensembl	ENSG00000172680	ENSMUSG00000078365
UniProt	P00540	n/a
RefSeq (mRNA)	NM_005372	NM_020021.2
RefSeq (protein)	NP_005363	NP_064405.2
Location (UCSC)	Chr 8: 57.03 – 57.03 Mb	Chr 4: 3.8 – 3.8 Mb
PubMed search	[1]	[2]

Proto-oncogene serine/threonine-protein kinase mos is an enzyme that in humans is encoded by the MOS gene.

Interactions

MOS (gene) has been shown to interact with MyoD.

Further reading

• Sagata N (1997). "What does Mos do in oocytes and somatic cells?". Bioessays 19 (1): 13–21. doi:10.1002/bies.950190105. PMID 9008413. 
• Caubet JF, Mathieu-Mahul D, Bernheim A, et al. (1986). "Human proto-oncogene c-mos maps to 8q11.". EMBO J. 4 (9): 2245–8. PMC 554492. PMID 3000766. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=554492. 
• Watson R, Oskarsson M, Vande Woude GF (1982). "Human DNA sequence homologous to the transforming gene (mos) of Moloney murine sarcoma virus.". Proc. Natl. Acad. Sci. U.S.A. 79 (13): 4078–82. doi:10.1073/pnas.79.13.4078. PMC 346580. PMID 6287464. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=346580. 
• Heikinheimo O, Lanzendorf SE, Baka SG, Gibbons WE (1995). "Cell cycle genes c-mos and cyclin-B1 are expressed in a specific pattern in human oocytes and preimplantation embryos.". Hum. Reprod. 10 (3): 699–707. PMID 7540181. 
• Lenormand JL, Benayoun B, Guillier M, et al. (1997). "Mos activates myogenic differentiation by promoting heterodimerization of MyoD and E12 proteins.". Mol. Cell. Biol. 17 (2): 584–93. PMC 231783. PMID 9001211. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=231783. 
• Liu H, Vuyyuru VB, Pham CD, et al. (1999). "Evidence of an interaction between Mos and Hsp70: a role of the Mos residue serine 3 in mediating Hsp70 association.". Oncogene 18 (23): 3461–70. doi:10.1038/sj.onc.1202699. PMID 10376524. 
• Pham CD, Vuyyuru VB, Yang Y, et al. (1999). "Evidence for an important role of serine 16 and its phosphorylation in the stabilization of c-Mos.". Oncogene 18 (30): 4287–94. doi:10.1038/sj.onc.1202804. PMID 10439036. 
• Proikas-Cezanne T, Stabel S, Riethmacher D (2002). "Identification of protein tyrosine phosphatase 1B and casein as substrates for 124-v-Mos.". BMC Biochem. 3: 6. doi:10.1186/1471-2091-3-6. PMC 102758. PMID 12022922. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=102758. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Hassel S, Eichner A, Yakymovych M, et al. (2004). "Proteins associated with type II bone morphogenetic protein receptor (BMPR-II) and identified by two-dimensional gel electrophoresis and mass spectrometry.". Proteomics 4 (5): 1346–58. doi:10.1002/pmic.200300770. PMID 15188402. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Kalejs M, Ivanov A, Plakhins G, et al. (2006). "Upregulation of meiosis-specific genes in lymphoma cell lines following genotoxic insult and induction of mitotic catastrophe.". BMC Cancer 6: 6. doi:10.1186/1471-2407-6-6. PMC 1351196. PMID 16401344. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1351196.