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Multiple PDZ domain protein
Protein MPDZ PDB 2fcf.png
PDB rendering based on 2fcf.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols MPDZ ; HYC2; MUPP1
External IDs OMIM603785 MGI1343489 HomoloGene2841 GeneCards: MPDZ Gene
RNA expression pattern
PBB GE MPDZ 205079 s at tn.png
PBB GE MPDZ 213306 at tn.png
More reference expression data
Species Human Mouse
Entrez 8777 17475
Ensembl ENSG00000107186 ENSMUSG00000028402
UniProt O75970 Q8VBX6
RefSeq (mRNA) NM_001261406 NM_010820
RefSeq (protein) NP_001248335 NP_034950
Location (UCSC) Chr 9:
13.11 – 13.28 Mb
Chr 4:
81.28 – 81.44 Mb
PubMed search [1] [2]

Multiple PDZ domain protein is a protein that in humans is encoded by the MPDZ gene.[1]


MPDZ has been shown to interact with:


  1. ^ "Entrez Gene: MPDZ multiple PDZ domain protein". 
  2. ^ Becamel C, Figge A, Poliak S, Dumuis A, Peles E, Bockaert J et al. (April 2001). "Interaction of serotonin 5-hydroxytryptamine type 2C receptors with PDZ10 of the multi-PDZ domain protein MUPP1". J. Biol. Chem. 276 (16): 12974–82. doi:10.1074/jbc.M008089200. PMID 11150294. 
  3. ^ Ullmer C, Schmuck K, Figge A, Lübbert H (March 1998). "Cloning and characterization of MUPP1, a novel PDZ domain protein". FEBS Lett. 424 (1-2): 63–8. doi:10.1016/s0014-5793(98)00141-0. PMID 9537516. 
  4. ^ Mancini A, Koch A, Stefan M, Niemann H, Tamura T (September 2000). "The direct association of the multiple PDZ domain containing proteins (MUPP-1) with the human c-Kit C-terminus is regulated by tyrosine kinase activity". FEBS Lett. 482 (1-2): 54–8. doi:10.1016/s0014-5793(00)02036-6. PMID 11018522. 
  5. ^ Kimber WA, Trinkle-Mulcahy L, Cheung PC, Deak M, Marsden LJ, Kieloch A et al. (February 2002). "Evidence that the tandem-pleckstrin-homology-domain-containing protein TAPP1 interacts with Ptd(3,4)P2 and the multi-PDZ-domain-containing protein MUPP1 in vivo". Biochem. J. 361 (Pt 3): 525–36. doi:10.1042/0264-6021:3610525. PMC 1222335. PMID 11802782. 

Further reading[edit]