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Multiple PDZ domain protein
Protein MPDZ PDB 2fcf.png
PDB rendering based on 2fcf.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols MPDZ ; HYC2; MUPP1
External IDs OMIM603785 MGI1343489 HomoloGene2841 GeneCards: MPDZ Gene
RNA expression pattern
PBB GE MPDZ 205079 s at tn.png
PBB GE MPDZ 213306 at tn.png
More reference expression data
Species Human Mouse
Entrez 8777 17475
Ensembl ENSG00000107186 ENSMUSG00000028402
UniProt O75970 Q8VBX6
RefSeq (mRNA) NM_001261406 NM_010820
RefSeq (protein) NP_001248335 NP_034950
Location (UCSC) Chr 9:
13.11 – 13.28 Mb
Chr 4:
81.28 – 81.44 Mb
PubMed search [1] [2]

Multiple PDZ domain protein is a protein that in humans is encoded by the MPDZ gene.[1]


MPDZ has been shown to interact with CD117,[2] PLEKHA1[3] and 5-HT2C receptor.[4][5]


  1. ^ "Entrez Gene: MPDZ multiple PDZ domain protein". 
  2. ^ Mancini, A; Koch A; Stefan M; Niemann H; Tamura T (September 2000). "The direct association of the multiple PDZ domain containing proteins (MUPP-1) with the human c-Kit C-terminus is regulated by tyrosine kinase activity". FEBS Lett. (NETHERLANDS) 482 (1–2): 54–8. doi:10.1016/S0014-5793(00)02036-6. ISSN 0014-5793. PMID 11018522. 
  3. ^ Kimber, Wendy A; Trinkle-Mulcahy Laura, Cheung Peter C F, Deak Maria, Marsden Louisa J, Kieloch Agnieszka, Watt Stephen, Javier Ronald T, Gray Alex, Downes C Peter, Lucocq John M, Alessi Dario R (February 2002). "Evidence that the tandem-pleckstrin-homology-domain-containing protein TAPP1 interacts with Ptd(3,4)P2 and the multi-PDZ-domain-containing protein MUPP1 in vivo". Biochem. J. (England) 361 (Pt 3): 525–36. doi:10.1042/0264-6021:3610525. ISSN 0264-6021. PMC 1222335. PMID 11802782. 
  4. ^ Becamel, C; Figge A; Poliak S; Dumuis A; Peles E; Bockaert J; Lubbert H; Ullmer C (April 2001). "Interaction of serotonin 5-hydroxytryptamine type 2C receptors with PDZ10 of the multi-PDZ domain protein MUPP1". J. Biol. Chem. (United States) 276 (16): 12974–82. doi:10.1074/jbc.M008089200. ISSN 0021-9258. PMID 11150294. 
  5. ^ Ullmer, C; Schmuck K; Figge A; Lübbert H (March 1998). "Cloning and characterization of MUPP1, a novel PDZ domain protein". FEBS Lett. (NETHERLANDS) 424 (1–2): 63–8. doi:10.1016/S0014-5793(98)00141-0. ISSN 0014-5793. PMID 9537516. 

Further reading[edit]