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Membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)
Protein MPP5 PDB 1va8.png
PDB rendering based on 1va8.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols MPP5 ; PALS1
External IDs OMIM606958 MGI1927339 HomoloGene9512 GeneCards: MPP5 Gene
RNA expression pattern
PBB GE MPP5 219321 at tn.png
More reference expression data
Species Human Mouse
Entrez 64398 56217
Ensembl ENSG00000072415 ENSMUSG00000021112
UniProt Q8N3R9 Q9JLB2
RefSeq (mRNA) NM_001256550 NM_019579
RefSeq (protein) NP_001243479 NP_062525
Location (UCSC) Chr 14:
67.71 – 67.8 Mb
Chr 12:
78.75 – 78.84 Mb
PubMed search [1] [2]

MAGUK p55 subfamily member 5 is a protein that in humans is encoded by the MPP5 gene.[1][2]

Members of the peripheral membrane-associated guanylate kinase (MAGUK) family function in tumor suppression and receptor clustering by forming multiprotein complexes containing distinct sets of transmembrane, cytoskeletal, and cytoplasmic signaling proteins. All MAGUKs contain a PDZ-SH3-GUK core and are divided into 4 subfamilies, DLG-like (see DLG1; MIM 601014), ZO1-like (see TJP1; MIM 601009), p55-like (see MPP1; MIM 305360), and LIN2-like (see CASK; MIM 300172), based on their size and the presence of additional domains (Tseng et al., 2001). MPP5 is a member of the p55-like MAGUK subfamily.[supplied by OMIM][2]


MPP5 has been shown to interact with INADL.[1]


Further reading[edit]