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Mitochondrial ribosomal protein L1
PBB Protein MRPL11 image.jpg
PDB rendering based on 2ftc.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols MRPL1 ; BM022; L1MT; MRP-L1
External IDs OMIM611821 MGI2137202 HomoloGene41355 GeneCards: MRPL1 Gene
Species Human Mouse
Entrez 65008 94061
Ensembl ENSG00000169288 ENSMUSG00000029486
UniProt Q9BYD6 Q99N96
RefSeq (mRNA) NM_020236 NM_001039084
RefSeq (protein) NP_064621 NP_001034173
Location (UCSC) Chr 4:
78.78 – 78.87 Mb
Chr 5:
96.21 – 96.27 Mb
PubMed search [1] [2]

39S ribosomal protein L1, mitochondrial is a protein that in humans is encoded by the MRPL1 gene.[1]

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the L1 ribosomal protein family.[1]


Further reading[edit]