MRPL10

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Mitochondrial ribosomal protein L10
Identifiers
Symbols MRPL10 ; L10MT; MRP-L10; MRP-L8; MRPL8; RPML8
External IDs OMIM611825 MGI1333801 HomoloGene41665 GeneCards: MRPL10 Gene
Orthologs
Species Human Mouse
Entrez 124995 107732
Ensembl ENSG00000159111 ENSMUSG00000001445
UniProt Q7Z7H8 Q3TBW2
RefSeq (mRNA) NM_145255 NM_026154
RefSeq (protein) NP_660298 NP_080430
Location (UCSC) Chr 17:
45.9 – 45.91 Mb
Chr 11:
97.04 – 97.05 Mb
PubMed search [1] [2]

39S ribosomal protein L10, mitochondrial is a protein that in humans is encoded by the MRPL10 gene.[1][2]

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Sequence analysis identified two transcript variants that encode different isoforms. A pseudogene corresponding to this gene is found on chromosome 5q.[2]

References[edit]

  1. ^ Koc EC, Burkhart W, Blackburn K, Moyer MB, Schlatzer DM, Moseley A, Spremulli LL (Nov 2001). "The large subunit of the mammalian mitochondrial ribosome. Analysis of the complement of ribosomal proteins present". J Biol Chem 276 (47): 43958–69. doi:10.1074/jbc.M106510200. PMID 11551941. 
  2. ^ a b "Entrez Gene: MRPL10 mitochondrial ribosomal protein L10". 

Further reading[edit]