MRPL17

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Mitochondrial ribosomal protein L17
Protein MRPL17 PDB 2cqm.png
PDB rendering based on 2cqm.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols MRPL17 ; L17mt; LIP2; MRP-L17; MRP-L26; RPL17L; RPML26
External IDs OMIM611830 MGI1351608 HomoloGene32526 GeneCards: MRPL17 Gene
RNA expression pattern
PBB GE MRPL17 222216 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 63875 27397
Ensembl ENSG00000158042 ENSMUSG00000030879
UniProt Q9NRX2 Q9D8P4
RefSeq (mRNA) NM_022061 NM_025301
RefSeq (protein) NP_071344 NP_079577
Location (UCSC) Chr 11:
6.7 – 6.7 Mb
Chr 7:
105.81 – 105.81 Mb
PubMed search [1] [2]

39S ribosomal protein L17, mitochondrial is a protein that in humans is encoded by the MRPL17 gene.[1]

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein.[1]

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