MRPL20

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Mitochondrial ribosomal protein L20
PBB Protein MRPL11 image.jpg
PDB rendering based on 2ftc.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols MRPL20 ; L20mt; MRP-L20
External IDs OMIM611833 HomoloGene9941 GeneCards: MRPL20 Gene
Orthologs
Species Human Mouse
Entrez 55052 66448
Ensembl ENSG00000242485 ENSMUSG00000029066
UniProt Q9BYC9 Q9CQL4
RefSeq (mRNA) NM_017971 NM_025570
RefSeq (protein) NP_060441 NP_079846
Location (UCSC) Chr 1:
1.4 – 1.41 Mb
Chr 4:
155.8 – 155.81 Mb
PubMed search [1] [2]

39S ribosomal protein L20, mitochondrial is a protein that in humans is encoded by the MRPL20 gene.[1]

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. A pseudogene corresponding to this gene is found on chromosome 21q.[1]

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