MRPL33

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Mitochondrial ribosomal protein L33
Protein MRPL33 PDB 2ftc.png
Rendering based on PDB 2ftc.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols MRPL33 ; C2orf1; L33mt; MRP-L33; RPL33L
External IDs OMIM610059 MGI2137225 HomoloGene81733 GeneCards: MRPL33 Gene
RNA expression pattern
PBB GE MRPL33 203781 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 9553 66845
Ensembl ENSG00000243147 ENSMUSG00000029142
UniProt O75394 Q9CQP0
RefSeq (mRNA) NM_004891 NM_025796
RefSeq (protein) NP_004882 NP_080072
Location (UCSC) Chr 2:
27.99 – 28.21 Mb
Chr 5:
31.6 – 31.7 Mb
PubMed search [1] [2]

39S ribosomal protein L33, mitochondrial is a protein that in humans is encoded by the MRPL33 gene.[1]

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Alternatively spliced transcript variants encoding different isoforms have been described.[1]

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