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Mitochondrial ribosomal protein L33
Protein MRPL33 PDB 2ftc.png
Rendering based on PDB 2ftc.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols MRPL33 ; C2orf1; L33mt; MRP-L33; RPL33L
External IDs OMIM610059 MGI2137225 HomoloGene81733 GeneCards: MRPL33 Gene
RNA expression pattern
PBB GE MRPL33 203781 at tn.png
More reference expression data
Species Human Mouse
Entrez 9553 66845
Ensembl ENSG00000243147 ENSMUSG00000029142
UniProt O75394 Q9CQP0
RefSeq (mRNA) NM_004891 NM_025796
RefSeq (protein) NP_004882 NP_080072
Location (UCSC) Chr 2:
27.99 – 28.21 Mb
Chr 5:
31.6 – 31.7 Mb
PubMed search [1] [2]

39S ribosomal protein L33, mitochondrial is a protein that in humans is encoded by the MRPL33 gene.[1]

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Alternatively spliced transcript variants encoding different isoforms have been described.[1]


Further reading[edit]