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Mitochondrial ribosomal protein S11
Symbols MRPS11 ; HCC-2
External IDs OMIM611977 MGI1915244 HomoloGene32554 GeneCards: MRPS11 Gene
RNA expression pattern
PBB GE MRPS11 211595 s at tn.png
More reference expression data
Species Human Mouse
Entrez 64963 67994
Ensembl ENSG00000181991 ENSMUSG00000030611
UniProt P82912 Q3U8Y1
RefSeq (mRNA) NM_022839 NM_026498
RefSeq (protein) NP_073750 NP_080774
Location (UCSC) Chr 15:
89.01 – 89.02 Mb
Chr 7:
78.78 – 78.79 Mb
PubMed search [1] [2]

28S ribosomal protein S11, mitochondrial is a protein that in humans is encoded by the MRPS11 gene.[1][2]


Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that contains a high level of sequence similarity with ribosomal protein S11P family members.[2]


  1. ^ Suzuki T, Terasaki M, Takemoto-Hori C, Hanada T, Ueda T, Wada A, Watanabe K (Aug 2001). "Proteomic analysis of the mammalian mitochondrial ribosome. Identification of protein components in the 28 S small subunit". J Biol Chem 276 (35): 33181–95. doi:10.1074/jbc.M103236200. PMID 11402041. 
  2. ^ a b "Entrez Gene: MRPS11 mitochondrial ribosomal protein S11". 

Further reading[edit]