MRPS16

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Mitochondrial ribosomal protein S16
Identifiers
Symbols MRPS16 ; COXPD2; MRP-S16; RPMS16
External IDs OMIM609204 MGI1913492 HomoloGene9370 GeneCards: MRPS16 Gene
Orthologs
Species Human Mouse
Entrez 51021 66242
Ensembl ENSG00000182180 ENSMUSG00000049960
UniProt Q9Y3D3 Q9CPX7
RefSeq (mRNA) NM_016065 NM_025440
RefSeq (protein) NP_057149 NP_079716
Location (UCSC) Chr 10:
75.01 – 75.01 Mb
Chr 14:
20.39 – 20.39 Mb
PubMed search [1] [2]

28S ribosomal protein S16, mitochondrial is a protein that in humans is encoded by the MRPS16 gene.[1][2]

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S16P family. The encoded protein is one of the most highly conserved ribosomal proteins between mammalian and yeast mitochondria. Three pseudogenes (located at 8q21.3, 20q13.32, 22q12-q13.1) for this gene have been described.[2]

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