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Mitochondrial ribosomal protein S7
Symbols MRPS7 ; MRP-S; MRP-S7; RP-S7; RPMS7; S7mt; bMRP27a
External IDs OMIM611974 MGI1354367 HomoloGene9321 GeneCards: MRPS7 Gene
RNA expression pattern
PBB GE MRPS7 217932 at tn.png
More reference expression data
Species Human Mouse
Entrez 51081 50529
Ensembl ENSG00000125445 ENSMUSG00000046756
UniProt Q9Y2R9 Q80X85
RefSeq (mRNA) NM_015971 NM_025305
RefSeq (protein) NP_057055 NP_079581
Location (UCSC) Chr 17:
73.26 – 73.26 Mb
Chr 11:
115.6 – 115.61 Mb
PubMed search [1] [2]

28S ribosomal protein S7, mitochondrial is a protein that in humans is encoded by the MRPS7 gene.[1]

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein. In the prokaryotic ribosome, the comparable protein is thought to play an essential role in organizing the 3' domain of the 16 S rRNA in the vicinity of the P- and A-sites. Pseudogenes corresponding to this gene are found on chromosomes 8p and 12p.[1]


Further reading[edit]