MRS-1706

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MRS-1706
MRS1706 structure.png
Identifiers
CAS number 264622-53-9 YesY
PubChem 5139184
ChemSpider 4313008 N
MeSH C496145
Jmol-3D images Image 1
Properties
Molecular formula C27H29N5O5
Molar mass 503.56
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
 N (verify) (what is: YesY/N?)
Infobox references

MRS-1706 is a selective inverse agonist for the adenosine A2B receptor.[1] It inhibits release of interleukins and has an antiinflammatory effect.[2][3]

References[edit]

  1. ^ Li Q, Ye K, Blad CC, den Dulk H, Brouwer J, Ijzerman AP, Beukers MW. ZM241385, DPCPX, MRS1706 are inverse agonists with different relative intrinsic efficacies on constitutively active mutants of the human adenosine A2B receptor. Journal of Pharmacology and Experimental Therapeutics. 2007 Feb;320(2):637-45. PMID 17077318
  2. ^ Vazquez JF, Clement HW, Sommer O, Schulz E, van Calker D. Local stimulation of the adenosine A2B receptors induces an increased release of IL-6 in mouse striatum: an in vivo microdialysis study. Journal of Neurochemistry. 2008 May;105(3):904-9. PMID 18088370
  3. ^ Ryzhov S, Zaynagetdinov R, Goldstein AE, Novitskiy SV, Dikov MM, Blackburn MR, Biaggioni I, Feoktistov I. Effect of A2B adenosine receptor gene ablation on proinflammatory adenosine signaling in mast cells. Journal of Immunology. 2008 Jun 1;180(11):7212-20. PMID 18490720