MS4A2

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Membrane-spanning 4-domains, subfamily A, member 2
Identifiers
Symbols MS4A2 ; APY; ATOPY; FCER1B; FCERI; IGEL; IGER; IGHER; MS4A1
External IDs OMIM147138 MGI95495 HomoloGene112 GeneCards: MS4A2 Gene
RNA expression pattern
PBB GE MS4A2 207497 s at tn.png
PBB GE MS4A2 207496 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 2206 14126
Ensembl ENSG00000149534 ENSMUSG00000024680
UniProt Q01362 P20490
RefSeq (mRNA) NM_000139 NM_001276328
RefSeq (protein) NP_000130 NP_001263257
Location (UCSC) Chr 11:
59.86 – 59.86 Mb
Chr 19:
11.62 – 11.62 Mb
PubMed search [1] [2]

High affinity immunoglobulin epsilon receptor subunit beta is a protein that in humans is encoded by the MS4A2 gene.[1][1][2]

Function[edit]

The allergic response involves the binding of allergen to receptor-bound IgE followed by cell activation and the release of mediators responsible for the manifestations of allergy. The IgE-receptor, a tetramer composed of an alpha, beta, and 2 disulfide-linked gamma chains, is found on the surface of mast cells and basophils. This gene encodes the beta subunit of the high affinity IgE receptor which is a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This family member is localized to 11q12, among a cluster of family members.[2]

See also[edit]

References[edit]

  1. ^ a b Maekawa K, Imagawa N, Tanaka Y, Harada S (Aug 1992). "Determination of the sequence coding for the beta subunit of the human high-affinity IgE receptor". FEBS Lett 302 (2): 161–5. doi:10.1016/0014-5793(92)80430-O. PMID 1386024. 
  2. ^ a b "Entrez Gene: MS4A2 membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide)". 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.