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Membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
Symbols MS4A3 ; CD20L; HTM4
External IDs OMIM606498 MGI2158468 HomoloGene4472 GeneCards: MS4A3 Gene
RNA expression pattern
PBB GE MS4A3 210254 at tn.png
More reference expression data
Species Human Mouse
Entrez 932 170813
Ensembl ENSG00000149516 ENSMUSG00000024681
UniProt Q96HJ5 Q920C4
RefSeq (mRNA) NM_001031666 NM_133246
RefSeq (protein) NP_001026836 NP_573509
Location (UCSC) Chr 11:
59.82 – 59.84 Mb
Chr 19:
11.63 – 11.64 Mb
PubMed search [1] [2]

Membrane-spanning 4-domains subfamily A member 3 is a protein that in humans is encoded by the MS4A3 gene.[1][2]

This gene encodes a member of the membrane-spanning 4A gene family. Members of this protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This family member likely plays a role in signal transduction and may function as a subunit associated with receptor complexes. The gene encoding this protein is localized to 11q12, among a cluster of related family members. Alternative splicing may result in multiple transcript variants; however, not all variants have been fully described.[2]


MS4A3 has been shown to interact with CDKN3.[3]


  1. ^ Adra CN, Lelias JM, Kobayashi H, Kaghad M, Morrison P, Rowley JD, Lim B (Nov 1994). "Cloning of the cDNA for a hematopoietic cell-specific protein related to CD20 and the beta subunit of the high-affinity IgE receptor: evidence for a family of proteins with four membrane-spanning regions". Proc Natl Acad Sci U S A 91 (21): 10178–82. doi:10.1073/pnas.91.21.10178. PMC 44981. PMID 7524084. 
  2. ^ a b "Entrez Gene: MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)". 
  3. ^ Donato, José L; Ko Jon; Kutok Jeffery L; Cheng Tao; Shirakawa Taro; Mao Xiao-Quan; Beach David; Scadden David T; Sayegh Mohamed H; Adra Chaker N (Jan 2002). "Human HTm4 is a hematopoietic cell cycle regulator". J. Clin. Invest. (United States) 109 (1): 51–8. doi:10.1172/JCI14025. ISSN 0021-9738. PMC 150822. PMID 11781350. 

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