MS4A3

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Membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
Identifiers
Symbols MS4A3 ; CD20L; HTM4
External IDs OMIM606498 MGI2158468 HomoloGene4472 GeneCards: MS4A3 Gene
RNA expression pattern
PBB GE MS4A3 210254 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 932 170813
Ensembl ENSG00000149516 ENSMUSG00000024681
UniProt Q96HJ5 Q920C4
RefSeq (mRNA) NM_001031666 NM_133246
RefSeq (protein) NP_001026836 NP_573509
Location (UCSC) Chr 11:
59.82 – 59.84 Mb
Chr 19:
11.63 – 11.64 Mb
PubMed search [1] [2]

Membrane-spanning 4-domains subfamily A member 3 is a protein that in humans is encoded by the MS4A3 gene.[1][2]

This gene encodes a member of the membrane-spanning 4A gene family. Members of this protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This family member likely plays a role in signal transduction and may function as a subunit associated with receptor complexes. The gene encoding this protein is localized to 11q12, among a cluster of related family members. Alternative splicing may result in multiple transcript variants; however, not all variants have been fully described.[2]

Interactions[edit]

MS4A3 has been shown to interact with CDKN3.[3]

References[edit]

  1. ^ Adra CN, Lelias JM, Kobayashi H, Kaghad M, Morrison P, Rowley JD, Lim B (Nov 1994). "Cloning of the cDNA for a hematopoietic cell-specific protein related to CD20 and the beta subunit of the high-affinity IgE receptor: evidence for a family of proteins with four membrane-spanning regions". Proc Natl Acad Sci U S A 91 (21): 10178–82. doi:10.1073/pnas.91.21.10178. PMC 44981. PMID 7524084. 
  2. ^ a b "Entrez Gene: MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)". 
  3. ^ Donato, José L; Ko Jon, Kutok Jeffery L, Cheng Tao, Shirakawa Taro, Mao Xiao-Quan, Beach David, Scadden David T, Sayegh Mohamed H, Adra Chaker N (Jan 2002). "Human HTm4 is a hematopoietic cell cycle regulator". J. Clin. Invest. (United States) 109 (1): 51–8. doi:10.1172/JCI14025. ISSN 0021-9738. PMC 150822. PMID 11781350. 

Further reading[edit]