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Membrane-spanning 4-domains, subfamily A, member 7
Symbols MS4A7 ; 4SPAN2; CD20L4; CFFM4; MS4A8
External IDs OMIM606502 MGI1918846 HomoloGene10922 GeneCards: MS4A7 Gene
Species Human Mouse
Entrez 58475 109225
Ensembl ENSG00000166927 ENSMUSG00000024672
UniProt Q9GZW8 Q99N04
RefSeq (mRNA) NM_021201 NM_001025610
RefSeq (protein) NP_067024 NP_001020781
Location (UCSC) Chr 11:
60.15 – 60.16 Mb
Chr 19:
11.32 – 11.34 Mb
PubMed search [1] [2]

Membrane-spanning 4-domains subfamily A member 7 is a protein that in humans is encoded by the MS4A7 gene.[1][2][3]

This gene encodes a member of the membrane-spanning 4A gene family, members of which are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns in hematopoietic cells and nonlymphoid tissues. This family member is associated with mature cellular function in the monocytic lineage, and it may be a component of a receptor complex involved in signal transduction. This gene is localized to 11q12, in a cluster of other family members. At least four alternatively spliced transcript variants encoding two distinct isoforms have been observed.[3]


  1. ^ Ishibashi K, Suzuki M, Sasaki S, Imai M (Mar 2001). "Identification of a new multigene four-transmembrane family (MS4A) related to CD20, HTm4 and beta subunit of the high-affinity IgE receptor". Gene 264 (1): 87–93. doi:10.1016/S0378-1119(00)00598-9. PMID 11245982. 
  2. ^ Liang Y, Tedder TF (Jun 2001). "Identification of a CD20-, FcepsilonRIbeta-, and HTm4-related gene family: sixteen new MS4A family members expressed in human and mouse". Genomics 72 (2): 119–27. doi:10.1006/geno.2000.6472. PMID 11401424. 
  3. ^ a b "Entrez Gene: MS4A7 membrane-spanning 4-domains, subfamily A, member 7". 

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