MSH4
From Wikipedia, the free encyclopedia
| MutS homolog 4 (E. coli) | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | MSH4; | ||||||||||||
| External IDs | OMIM: 602105 MGI: 1860077 HomoloGene: 1830 GeneCards: MSH4 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 4438 | 55993 | |||||||||||
| Ensembl | ENSG00000057468 | ENSMUSG00000005493 | |||||||||||
| UniProt | O15457 | Q7TMA3 | |||||||||||
| RefSeq (mRNA) | NM_002440 | NM_031870.2 | |||||||||||
| RefSeq (protein) | NP_002431 | NP_114076.1 | |||||||||||
| Location (UCSC) | Chr 1: 76.26 – 76.38 Mb |
Chr 3: 153.52 – 153.57 Mb |
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| PubMed search | [1] | [2] | |||||||||||
MutS protein homolog 4 is a protein that in humans is encoded by the MSH4 gene.[1][2]
Contents |
[edit] Interactions
MSH4 has been shown to interact with MLH1,[3] MSH5[4][5][6] and MLH3.[7]
[edit] References
- ^ Paquis-Flucklinger V, Santucci-Darmanin S, Paul R, Saunieres A, Turc-Carel C, Desnuelle C (Dec 1997). "Cloning and expression analysis of a meiosis-specific MutS homolog: the human MSH4 gene". Genomics 44 (2): 188–94. doi:10.1006/geno.1997.4857. PMID 9299235.
- ^ "Entrez Gene: MSH4 mutS homolog 4 (E. coli)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4438.
- ^ Santucci-Darmanin, S; Walpita D, Lespinasse F, Desnuelle C, Ashley T, Paquis-Flucklinger V (Aug. 2000). "MSH4 acts in conjunction with MLH1 during mammalian meiosis". FASEB J. (UNITED STATES) 14 (11): 1539–47. doi:10.1096/fj.14.11.1539. ISSN 0892-6638. PMID 10928988.
- ^ Her, Chengtao; Wu Xiling, Griswold Michael D, Zhou Feng (Feb. 2003). "Human MutS homologue MSH4 physically interacts with von Hippel-Lindau tumor suppressor-binding protein 1". Cancer Res. (United States) 63 (4): 865–72. ISSN 0008-5472. PMID 12591739.
- ^ Winand, N J; Panzer J A, Kolodner R D (Oct. 1998). "Cloning and characterization of the human and Caenorhabditis elegans homologs of the Saccharomyces cerevisiae MSH5 gene". Genomics (UNITED STATES) 53 (1): 69–80. doi:10.1006/geno.1998.5447. ISSN 0888-7543. PMID 9787078.
- ^ Bocker, T; Barusevicius A, Snowden T, Rasio D, Guerrette S, Robbins D, Schmidt C, Burczak J, Croce C M, Copeland T, Kovatich A J, Fishel R (Feb. 1999). "hMSH5: a human MutS homologue that forms a novel heterodimer with hMSH4 and is expressed during spermatogenesis". Cancer Res. (UNITED STATES) 59 (4): 816–22. ISSN 0008-5472. PMID 10029069.
- ^ Santucci-Darmanin, Sabine; Neyton Sophie, Lespinasse Françoise, Saunières Anne, Gaudray Patrick, Paquis-Flucklinger Véronique (Jul. 2002). "The DNA mismatch-repair MLH3 protein interacts with MSH4 in meiotic cells, supporting a role for this MutL homolog in mammalian meiotic recombination". Hum. Mol. Genet. (England) 11 (15): 1697–706. doi:10.1093/hmg/11.15.1697. ISSN 0964-6906. PMID 12095912.
[edit] Further reading
- Her C, Zhao N, Wu X, Tompkins JD (2007). "MutS homologues hMSH4 and hMSH5: diverse functional implications in humans.". Front. Biosci. 12: 905–11. doi:10.2741/2112. PMID 17127347.
- Winand NJ, Panzer JA, Kolodner RD (1998). "Cloning and characterization of the human and Caenorhabditis elegans homologs of the Saccharomyces cerevisiae MSH5 gene.". Genomics 53 (1): 69–80. doi:10.1006/geno.1998.5447. PMID 9787078.
- Bocker T, Barusevicius A, Snowden T, et al. (1999). "hMSH5: a human MutS homologue that forms a novel heterodimer with hMSH4 and is expressed during spermatogenesis.". Cancer Res. 59 (4): 816–22. PMID 10029069.
- Kneitz B, Cohen PE, Avdievich E, et al. (2000). "MutS homolog 4 localization to meiotic chromosomes is required for chromosome pairing during meiosis in male and female mice.". Genes Dev. 14 (9): 1085–97. PMC 316572. PMID 10809667. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=316572.
- Santucci-Darmanin S, Walpita D, Lespinasse F, et al. (2000). "MSH4 acts in conjunction with MLH1 during mammalian meiosis.". FASEB J. 14 (11): 1539–47. doi:10.1096/fj.14.11.1539. PMID 10928988.
- Räschle M, Dufner P, Marra G, Jiricny J (2002). "Mutations within the hMLH1 and hPMS2 subunits of the human MutLalpha mismatch repair factor affect its ATPase activity, but not its ability to interact with hMutSalpha.". J. Biol. Chem. 277 (24): 21810–20. doi:10.1074/jbc.M108787200. PMID 11948175.
- Moens PB, Kolas NK, Tarsounas M, et al. (2003). "The time course and chromosomal localization of recombination-related proteins at meiosis in the mouse are compatible with models that can resolve the early DNA-DNA interactions without reciprocal recombination.". J. Cell. Sci. 115 (Pt 8): 1611–22. PMID 11950880.
- Santucci-Darmanin S, Neyton S, Lespinasse F, et al. (2003). "The DNA mismatch-repair MLH3 protein interacts with MSH4 in meiotic cells, supporting a role for this MutL homolog in mammalian meiotic recombination.". Hum. Mol. Genet. 11 (15): 1697–706. doi:10.1093/hmg/11.15.1697. PMID 12095912.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Her C, Wu X, Griswold MD, Zhou F (2003). "Human MutS homologue MSH4 physically interacts with von Hippel-Lindau tumor suppressor-binding protein 1.". Cancer Res. 63 (4): 865–72. PMID 12591739.
- Snowden T, Acharya S, Butz C, et al. (2004). "hMSH4-hMSH5 recognizes Holliday Junctions and forms a meiosis-specific sliding clamp that embraces homologous chromosomes.". Mol. Cell 15 (3): 437–51. doi:10.1016/j.molcel.2004.06.040. PMID 15304223.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
- Yi W, Wu X, Lee TH, et al. (2005). "Two variants of MutS homolog hMSH5: prevalence in humans and effects on protein interaction.". Biochem. Biophys. Res. Commun. 332 (2): 524–32. doi:10.1016/j.bbrc.2005.04.154. PMID 15907804.
- Lee TH, Yi W, Griswold MD, et al. (2006). "Formation of hMSH4-hMSH5 heterocomplex is a prerequisite for subsequent GPS2 recruitment.". DNA Repair (Amst.) 5 (1): 32–42. doi:10.1016/j.dnarep.2005.07.004. PMID 16122992.
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Neyton S, Lespinasse F, Lahaye F, et al. (2007). "CRM1-dependent nuclear export and dimerization with hMSH5 contribute to the regulation of hMSH4 subcellular localization.". Exp. Cell Res. 313 (17): 3680–93. doi:10.1016/j.yexcr.2007.08.010. PMID 17869244.
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