MSH4

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MutS homolog 4 (E. coli)
Identifiers
Symbol MSH4
External IDs OMIM602105 MGI1860077 HomoloGene1830 GeneCards: MSH4 Gene
RNA expression pattern
PBB GE MSH4 210533 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 4438 55993
Ensembl ENSG00000057468 ENSMUSG00000005493
UniProt O15457 Q99MT2
RefSeq (mRNA) NM_002440 NM_031870
RefSeq (protein) NP_002431 NP_114076
Location (UCSC) Chr 1:
76.26 – 76.38 Mb
Chr 3:
153.86 – 153.91 Mb
PubMed search [1] [2]

MutS protein homolog 4 is a protein that in humans is encoded by the MSH4 gene.[1][2]


Interactions[edit]

MSH4 has been shown to interact with MLH1,[3] MSH5[4][5][6] and MLH3.[7]

References[edit]

  1. ^ Paquis-Flucklinger V, Santucci-Darmanin S, Paul R, Saunieres A, Turc-Carel C, Desnuelle C (December 1997). "Cloning and expression analysis of a meiosis-specific MutS homolog: the human MSH4 gene". Genomics 44 (2): 188–94. doi:10.1006/geno.1997.4857. PMID 9299235. 
  2. ^ "Entrez Gene: MSH4 mutS homolog 4 (E. coli)". 
  3. ^ Santucci-Darmanin, S; Walpita D, Lespinasse F, Desnuelle C, Ashley T, Paquis-Flucklinger V (August 2000). "MSH4 acts in conjunction with MLH1 during mammalian meiosis". FASEB J. (UNITED STATES) 14 (11): 1539–47. doi:10.1096/fj.14.11.1539. ISSN 0892-6638. PMID 10928988. 
  4. ^ Her, Chengtao; Wu Xiling, Griswold Michael D, Zhou Feng (February 2003). "Human MutS homologue MSH4 physically interacts with von Hippel-Lindau tumor suppressor-binding protein 1". Cancer Res. (United States) 63 (4): 865–72. ISSN 0008-5472. PMID 12591739. 
  5. ^ Winand, N J; Panzer J A, Kolodner R D (October 1998). "Cloning and characterization of the human and Caenorhabditis elegans homologs of the Saccharomyces cerevisiae MSH5 gene". Genomics (UNITED STATES) 53 (1): 69–80. doi:10.1006/geno.1998.5447. ISSN 0888-7543. PMID 9787078. 
  6. ^ Bocker, T; Barusevicius A, Snowden T, Rasio D, Guerrette S, Robbins D, Schmidt C, Burczak J, Croce C M, Copeland T, Kovatich A J, Fishel R (February 1999). "hMSH5: a human MutS homologue that forms a novel heterodimer with hMSH4 and is expressed during spermatogenesis". Cancer Res. (UNITED STATES) 59 (4): 816–22. ISSN 0008-5472. PMID 10029069. 
  7. ^ Santucci-Darmanin, Sabine; Neyton Sophie, Lespinasse Françoise, Saunières Anne, Gaudray Patrick, Paquis-Flucklinger Véronique (July 2002). "The DNA mismatch-repair MLH3 protein interacts with MSH4 in meiotic cells, supporting a role for this MutL homolog in mammalian meiotic recombination". Hum. Mol. Genet. (England) 11 (15): 1697–706. doi:10.1093/hmg/11.15.1697. ISSN 0964-6906. PMID 12095912. 

Further reading[edit]

External links[edit]