MSH5

MutS homolog 5 (E. coli)
Identifiers
Symbols	MSH5; DKFZp434C1615; G7; MGC2939; MUTSH5; NG23
External IDs	OMIM: 603382 MGI: 1329021 HomoloGene: 8415 GeneCards: MSH5 Gene
Gene Ontology Molecular function • nucleotide binding • damaged DNA binding • ATP binding • DNA-dependent ATPase activity • mismatched DNA binding Cellular component • synaptonemal complex • mismatch repair complex Biological process • meiotic mismatch repair • mismatch repair • meiosis • reciprocal meiotic recombination • meiotic prophase II • homologous chromosome segregation • chiasma assembly Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4439	17687
Ensembl	ENSG00000096474	ENSMUSG00000007035
UniProt	O43196	Q9R1I5
RefSeq (mRNA)	NM_002441.4	NM_013600
RefSeq (protein)	NP_002432.1	NP_038628
Location (UCSC)	Chr c6_COX: 31.84 – 31.87 Mb	Chr 17: 35.17 – 35.18 Mb
PubMed search	[1]	[2]

MutS protein homolog 5 is a protein that in humans is encoded by the MSH5 gene.

This gene encodes a member of the mutS family of proteins that are involved in DNA mismatch repair or meiotic recombination processes. This protein is similar to a Saccharomyces cerevisiae protein that participates in meiotic segregation fidelity and crossing-over. This protein forms heterooligomers with another member of this family, mutS homolog 4. Alternative splicing results in four transcript variants encoding three different isoforms.

Interactions

MSH5 has been shown to interact with MSH4.

Further reading

• Her C, Zhao N, Wu X, Tompkins JD (2007). "MutS homologues hMSH4 and hMSH5: diverse functional implications in humans.". Front. Biosci. 12: 905–11. doi:10.2741/2112. PMID 17127347. 
• Sargent CA, Dunham I, Campbell RD (1989). "Identification of multiple HTF-island associated genes in the human major histocompatibility complex class III region.". EMBO J. 8 (8): 2305–12. PMC 401163. PMID 2477242. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=401163. 
• Albertella MR, Jones H, Thomson W, et al. (1997). "Localization of eight additional genes in the human major histocompatibility complex, including the gene encoding the casein kinase II beta subunit (CSNK2B).". Genomics 36 (2): 240–51. doi:10.1006/geno.1996.0459. PMID 8812450. 
• Edelmann W, Cohen PE, Kneitz B, et al. (1999). "Mammalian MutS homologue 5 is required for chromosome pairing in meiosis.". Nat. Genet. 21 (1): 123–7. doi:10.1038/5075. PMID 9916805. 
• Bocker T, Barusevicius A, Snowden T, et al. (1999). "hMSH5: a human MutS homologue that forms a novel heterodimer with hMSH4 and is expressed during spermatogenesis.". Cancer Res. 59 (4): 816–22. PMID 10029069. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404. 
• Xie T, Rowen L, Aguado B, et al. (2004). "Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse.". Genome Res. 13 (12): 2621–36. doi:10.1101/gr.1736803. PMC 403804. PMID 14656967. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=403804. 
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
• Anderson NL, Polanski M, Pieper R, et al. (2004). "The human plasma proteome: a nonredundant list developed by combination of four separate sources.". Mol. Cell Proteomics 3 (4): 311–26. doi:10.1074/mcp.M300127-MCP200. PMID 14718574. 
• Snowden T, Acharya S, Butz C, et al. (2004). "hMSH4-hMSH5 recognizes Holliday Junctions and forms a meiosis-specific sliding clamp that embraces homologous chromosomes.". Mol. Cell 15 (3): 437–51. doi:10.1016/j.molcel.2004.06.040. PMID 15304223. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Yi W, Wu X, Lee TH, et al. (2005). "Two variants of MutS homolog hMSH5: prevalence in humans and effects on protein interaction.". Biochem. Biophys. Res. Commun. 332 (2): 524–32. doi:10.1016/j.bbrc.2005.04.154. PMID 15907804. 
• Lee TH, Yi W, Griswold MD, et al. (2006). "Formation of hMSH4-hMSH5 heterocomplex is a prerequisite for subsequent GPS2 recruitment.". DNA Repair (Amst.) 5 (1): 32–42. doi:10.1016/j.dnarep.2005.07.004. PMID 16122992. 
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
• Sekine H, Ferreira RC, Pan-Hammarström Q, et al. (2007). "Role for Msh5 in the regulation of Ig class switch recombination.". Proc. Natl. Acad. Sci. U.S.A. 104 (17): 7193–8. doi:10.1073/pnas.0700815104. PMC 1855370. PMID 17409188. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1855370. 
• Szafranski K, Schindler S, Taudien S, et al. (2007). "Violating the splicing rules: TG dinucleotides function as alternative 3' splice sites in U2-dependent introns.". Genome Biology 8 (8): R154. doi:10.1186/gb-2007-8-8-r154. PMC 2374985. PMID 17672918. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2374985.