MSMB

Microseminoprotein, beta-
PDB rendering based on 2iz3.
Available structures PDB 2IZ3, 3IX0
Identifiers
Symbols	MSMB; HPC13; IGBF; MSP; MSPB; PN44; PRPS; PSP; PSP-94; PSP57; PSP94
External IDs	OMIM: 157145 MGI: 97166 HomoloGene: 1832 GeneCards: MSMB Gene
Gene Ontology Molecular function • molecular_function Cellular component • extracellular region • extracellular space • nucleus Biological process • biological_process Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4477	17695
Ensembl	ENSG00000138294	ENSMUSG00000021907
UniProt	P08118	O08540
RefSeq (mRNA)	NM_002443.3	NM_020597.3
RefSeq (protein)	NP_002434.1	NP_065622.1
Location (UCSC)	Chr 10: 51.55 – 51.56 Mb	Chr 14: 32.96 – 32.97 Mb
PubMed search	[1]	[2]

Beta-microseminoprotein is a protein that in humans is encoded by the MSMB gene.

Function

Beta-microseminoprotein is a member of the immunoglobulin binding factor family. It is synthesized by the epithelial cells of the prostate gland and secreted into the seminal plasma. This protein has inhibin-like activity. It may have a role as an autocrine paracrine factor in uterine, breast and other female reproductive tissues. Two alternatively spliced transcript variants encoding different isoforms are described for this gene. The use of alternate polyadenylation sites has been found for this gene.

Clinical significance

The expression of beta-microseminoprotein is found to be decreased in prostate cancer. Furthermore decreased expression of the protein caused by the MSMB rs10993994 allele is associated with an increased risk of developing prostate cancer. Finally urinary MSMB has been found to be superior than urinary PSA at differentiating men with prostate cancer at all Gleason grades.

Further reading

• Liang ZG, Kamada M, Koide SS (1991). "Structural identity of immunoglobulin binding factor and prostatic secretory protein of human seminal plasma". Biochem. Biophys. Res. Commun. 180 (1): 356–9. doi:10.1016/S0006-291X(05)81300-2. PMID 1930232. 
• Nolet S, St-Louis D, Mbikay M, Chrétien M (1991). "Rapid evolution of prostatic protein PSP94 suggested by sequence divergence between rhesus monkey and human cDNAs". Genomics 9 (4): 775–7. doi:10.1016/0888-7543(91)90375-O. PMID 2037304. 
• Nolet S, Mbikay M, Chrétien M (1991). "Prostatic secretory protein PSP94: gene organization and promoter sequence in rhesus monkey and human". Biochim. Biophys. Acta 1089 (2): 247–9. PMID 2054385. 
• Green CB, Liu WY, Kwok SC (1990). "Cloning and nucleotide sequence analysis of the human beta-microseminoprotein gene". Biochem. Biophys. Res. Commun. 167 (3): 1184–90. doi:10.1016/0006-291X(90)90648-7. PMID 2322265. 
• Ito Y, Tsuda R, Kimura H (1989). "Ultrastructural localizations of beta-microseminoprotein, a prostate-specific antigen, in human prostate and sperm: comparison with gamma-seminoprotein, another prostate-specific antigen". J. Lab. Clin. Med. 114 (3): 272–7. PMID 2475560. 
• Ulvsbäck M, Lindström C, Weiber H et al. (1989). "Molecular cloning of a small prostate protein, known as beta-microsemenoprotein, PSP94 or beta-inhibin, and demonstration of transcripts in non-genital tissues". Biochem. Biophys. Res. Commun. 164 (3): 1310–5. doi:10.1016/0006-291X(89)91812-3. PMID 2590204. 
• Abrahamsson PA, Andersson C, Björk T et al. (1989). "Radioimmunoassay of beta-microseminoprotein, a prostatic-secreted protein present in sera of both men and women". Clin. Chem. 35 (7): 1497–503. PMID 2758596. 
• Mbikay M, Nolet S, Fournier S et al. (1987). "Molecular cloning and sequence of the cDNA for a 94-amino-acid seminal plasma protein secreted by the human prostate". DNA 6 (1): 23–9. doi:10.1089/dna.1987.6.23. PMID 3829888. 
• Akiyama K, Yoshioka Y, Schmid K et al. (1985). "The amino acid sequence of human beta-microseminoprotein". Biochim. Biophys. Acta 829 (2): 288–94. doi:10.1016/0167-4838(85)90200-6. PMID 3995056. 
• Seidah NG, Arbatti NJ, Rochemont J et al. (1984). "Complete amino acid sequence of human seminal plasma beta-inhibin. Prediction of post Gln-Arg cleavage as a maturation site". FEBS Lett. 175 (2): 349–55. doi:10.1016/0014-5793(84)80766-8. PMID 6434350. 
• Liu AY, Bradner RC, Vessella RL (1994). "Decreased expression of prostatic secretory protein PSP94 in prostate cancer". Cancer Lett. 74 (1–2): 91–9. doi:10.1016/0304-3835(93)90049-F. PMID 7506990. 
• Xuan JW, Chin JL, Guo Y et al. (1995). "Alternative splicing of PSP94 (prostatic secretory protein of 94 amino acids) mRNA in prostate tissue". Oncogene 11 (6): 1041–7. PMID 7566962. 
• Ochiai Y, Inazawa J, Ueyama H, Ohkubo I (1995). "Human gene for beta-microseminoprotein: its promoter structure and chromosomal localization". J. Biochem. 117 (2): 346–52. doi:10.1093/jb/117.2.346. PMID 7608123. 
• Ohkubo I, Tada T, Ochiai Y et al. (1995). "Human seminal plasma beta-microseminoprotein: its purification, characterization, and immunohistochemical localization". Int. J. Biochem. Cell Biol. 27 (6): 603–11. doi:10.1016/1357-2725(95)00021-G. PMID 7671139. 
• Fernlund P, Granberg LB, Roepstorff P (1994). "Amino acid sequence of beta-microseminoprotein from porcine seminal plasma". Arch. Biochem. Biophys. 309 (1): 70–6. doi:10.1006/abbi.1994.1086. PMID 8117114. 
• Sasaki T, Matsumoto N, Jinno Y et al. (1997). "Assignment of the human beta-microseminoprotein gene (MSMB) to chromosome 10q11.2". Cytogenet. Cell Genet. 72 (2–3): 177–8. doi:10.1159/000134180. PMID 8978767. 
• Kamada M, Mori H, Maeda N et al. (1998). "beta-Microseminoprotein/prostatic secretory protein is a member of immunoglobulin binding factor family". Biochim. Biophys. Acta 1388 (1): 101–10. doi:10.1016/S0167-4838(98)00164-2. PMID 9774712. 
• Mäkinen M, Valtonen-André C, Lundwall A (1999). "New world, but not Old World, monkeys carry several genes encoding beta-microseminoprotein". Eur. J. Biochem. 264 (2): 407–14. doi:10.1046/j.1432-1327.1999.00614.x. PMID 10491085. 
• Baijal-Gupta M, Clarke MW, Finkelman MA et al. (2000). "Prostatic secretory protein (PSP94) expression in human female reproductive tissues, breast and in endometrial cancer cell lines". J. Endocrinol. 165 (2): 425–33. doi:10.1677/joe.0.1650425. PMID 10810306.