Cytochrome c oxidase subunit II

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"COX2" redirects here. For the cyclooxygenase isoenzyme, see COX-2.
Cytochrome c oxidase subunit II
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols COX2 ; COII; MTCO2
External IDs OMIM516040 MGI102503 HomoloGene5017 ChEMBL: 6174 GeneCards: COX2 Gene
Orthologs
Species Human Mouse
Entrez 4513 17709
Ensembl ENSG00000198712 ENSMUSG00000064354
UniProt P00403 P00405
RefSeq (mRNA) n/a n/a
RefSeq (protein) n/a NP_904331
Location (UCSC) Chr MT:
0.01 – 0.01 Mb
Chr MT:
0.01 – 0.01 Mb
PubMed search [1] [2]
Cytochrome c oxidase subunit II, transmembrane domain
1qle opm.png
Bacterial cytochrome c oxidase complex. Subunit II indicated by blue.
Identifiers
Symbol COX2_TM
Pfam PF02790
InterPro IPR011759
PROSITE PDOC00075
SCOP 1occ
SUPERFAMILY 1occ
TCDB 3.D.4
OPM superfamily 4
OPM protein 1v55
Cytochrome C oxidase subunit II, periplasmic domain
Identifiers
Symbol COX2
Pfam PF00116
InterPro IPR002429
PROSITE PDOC00075
SCOP 1occ
SUPERFAMILY 1occ
TCDB 3.D.4
OPM superfamily 4
OPM protein 1v55

Cytochrome c oxidase subunit 2, also known as cytochrome c oxidase polypeptide II, is a protein that in humans is encoded by the MT-CO2 gene.[1]

Cytochrome c oxidase subunit II, abbreviated COXII, COX2, COII, or MT-CO2, is the second subunit of cytochrome c oxidase.

Cytochrome c oxidase (EC 1.9.3.1)[2][3] is an oligomeric enzymatic complex which is a component of the respiratory chain and is involved in the transfer of electrons from cytochrome c to oxygen. In eukaryotes this enzyme complex is located in the mitochondrial inner membrane; in aerobic prokaryotes it is found in the plasma membrane. The enzyme complex consists of 3-4 subunits (prokaryotes) to up to 13 polypeptides (mammals). In Leigh's disease, there may be an abnormality or deficiency of cytochrome oxidase.

Subunit 2 (COII) transfers the electrons from cytochrome c to the catalytic subunit 1. It contains two adjacent transmembrane regions in its N-terminus and the major part of the protein is exposed to the periplasmic or to the mitochondrial intermembrane space, respectively. COII provides the substrate-binding site and contains a copper centre called Cu(A) (see IPR001505), probably the primary acceptor in cytochrome c oxidase. An exception is the corresponding subunit of the cbb3-type oxidase which lacks the copper A redox-centre. Several bacterial COII have a C-terminal extension that contains a covalently bound haem c.

The N-terminal domain of cytochrome C oxidase contains two transmembrane alpha-helices.

References[edit]

  1. ^ "Entrez Gene: COX2 cytochrome c oxidase subunit II". 
  2. ^ Capaldi RA, Malatesta F, Darley-Usmar VM (July 1983). "Structure of cytochrome c oxidase". Biochim. Biophys. Acta 726 (2): 135–48. doi:10.1016/0304-4173(83)90003-4. PMID 6307356. 
  3. ^ García-Horsman JA, Barquera B, Rumbley J, Ma J, Gennis RB (September 1994). "The superfamily of heme-copper respiratory oxidases". J. Bacteriol. 176 (18): 5587–600. PMC 196760. PMID 8083153. 

Further reading[edit]

References[edit]