MTA2

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Metastasis associated 1 family, member 2
Identifiers
Symbols MTA2 ; MTA1L1; PID
External IDs OMIM603947 MGI1346340 HomoloGene3480 GeneCards: MTA2 Gene
RNA expression pattern
PBB GE MTA2 203443 at tn.png
PBB GE MTA2 203444 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 9219 23942
Ensembl ENSG00000149480 ENSMUSG00000071646
UniProt O94776 Q9R190
RefSeq (mRNA) NM_004739 NM_011842
RefSeq (protein) NP_004730 NP_035972
Location (UCSC) Chr 11:
62.36 – 62.37 Mb
Chr 19:
8.94 – 8.95 Mb
PubMed search [1] [2]

Metastasis-associated protein MTA2 is a protein that in humans is encoded by the MTA2 gene.[1][2]

This gene encodes a protein that has been identified as a component of NuRD, a nucleosome remodeling deacetylase complex identified in the nucleus of human cells. It shows a very broad expression pattern and is strongly expressed in many tissues. It may represent one member of a small gene family that encode different but related proteins involved either directly or indirectly in transcriptional regulation. Their indirect effects on transcriptional regulation may include chromatin remodeling. It is closely related to another member of this family, a protein that has been correlated with the metastatic potential of certain carcinomas. These two proteins are so closely related that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. One of the proteins known to be a target protein for this gene product is p53. Deacteylation of p53 is correlated with a loss of growth inhibition in transformed cells supporting a connection between these gene family members and metastasis.[2]

Interactions[edit]

MTA2 has been shown to interact with HDAC1,[3][4][5][6] Histone deacetylase 2,[3][5][7] MTA1,[3] CHD4,[3] RBBP7,[3][5] RBBP4,[3][5] MBD3[5][8][9] and SATB1.[6]

References[edit]

  1. ^ Futamura M, Nishimori H, Shiratsuchi T, Saji S, Nakamura Y, Tokino T (Mar 1999). "Molecular cloning, mapping, and characterization of a novel human gene, MTA1-L1, showing homology to a metastasis-associated gene, MTA1". J Hum Genet 44 (1): 52–6. doi:10.1007/s100380050107. PMID 9929979. 
  2. ^ a b "Entrez Gene: MTA2 metastasis associated 1 family, member 2". 
  3. ^ a b c d e f Yao, Ya-Li; Yang Wen-Ming (Oct 2003). "The metastasis-associated proteins 1 and 2 form distinct protein complexes with histone deacetylase activity". J. Biol. Chem. (United States) 278 (43): 42560–8. doi:10.1074/jbc.M302955200. ISSN 0021-9258. PMID 12920132. 
  4. ^ You, A; Tong J K, Grozinger C M, Schreiber S L (Feb 2001). "CoREST is an integral component of the CoREST- human histone deacetylase complex". Proc. Natl. Acad. Sci. U.S.A. (United States) 98 (4): 1454–8. doi:10.1073/pnas.98.4.1454. ISSN 0027-8424. PMC 29278. PMID 11171972. 
  5. ^ a b c d e Zhang, Y; Ng H H, Erdjument-Bromage H, Tempst P, Bird A, Reinberg D (Aug 1999). "Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation". Genes Dev. (UNITED STATES) 13 (15): 1924–35. doi:10.1101/gad.13.15.1924. ISSN 0890-9369. PMC 316920. PMID 10444591. 
  6. ^ a b Yasui, Dag; Miyano Masaru, Cai Shutao, Varga-Weisz Patrick, Kohwi-Shigematsu Terumi (Oct 2002). "SATB1 targets chromatin remodelling to regulate genes over long distances". Nature (England) 419 (6907): 641–5. doi:10.1038/nature01084. ISSN 0028-0836. PMID 12374985. 
  7. ^ Hakimi, Mohamed-Ali; Dong Yuanshu, Lane William S, Speicher David W, Shiekhattar Ramin (Feb 2003). "A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes". J. Biol. Chem. (United States) 278 (9): 7234–9. doi:10.1074/jbc.M208992200. ISSN 0021-9258. PMID 12493763. 
  8. ^ Sakai, Hirotaka; Urano Takeshi, Ookata Kayoko, Kim Mi-Hyun, Hirai Yugo, Saito Motoki, Nojima Yoshihisa, Ishikawa Fuyuki (Dec 2002). "MBD3 and HDAC1, two components of the NuRD complex, are localized at Aurora-A-positive centrosomes in M phase". J. Biol. Chem. (United States) 277 (50): 48714–23. doi:10.1074/jbc.M208461200. ISSN 0021-9258. PMID 12354758. 
  9. ^ Saito, Motoki; Ishikawa Fuyuki (Sep 2002). "The mCpG-binding domain of human MBD3 does not bind to mCpG but interacts with NuRD/Mi2 components HDAC1 and MTA2". J. Biol. Chem. (United States) 277 (38): 35434–9. doi:10.1074/jbc.M203455200. ISSN 0021-9258. PMID 12124384. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.