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Mitochondrial carrier 2
Symbols MTCH2 ; MIMP; SLC25A50
External IDs OMIM613221 MGI1929260 HomoloGene8645 GeneCards: MTCH2 Gene
Species Human Mouse
Entrez 23788 56428
Ensembl ENSG00000109919 ENSMUSG00000027282
UniProt Q9Y6C9 Q791V5
RefSeq (mRNA) NM_014342 NM_019758
RefSeq (protein) NP_055157 NP_062732
Location (UCSC) Chr 11:
47.64 – 47.66 Mb
Chr 2:
90.85 – 90.87 Mb
PubMed search [1] [2]

Mitochondrial carrier homolog 2 also known as MTCH2 is a protein which in humans is encoded by the MTCH2 gene.[1][2][3][4]

Clinical significance[edit]

Variants of the MTCH2 gene may be associated with obesity.[5]

See also[edit]


  1. ^ Grinberg M, Schwarz M, Zaltsman Y, Eini T, Niv H, Pietrokovski S, Gross A (June 2005). "Mitochondrial carrier homolog 2 is a target of tBID in cells signaled to die by tumor necrosis factor alpha". Mol. Cell. Biol. 25 (11): 4579–90. doi:10.1128/MCB.25.11.4579-4590.2005. PMC 1140633. PMID 15899861. 
  2. ^ Gross A (June 2005). "Mitochondrial carrier homolog 2: a clue to cracking the BCL-2 family riddle?". J. Bioenerg. Biomembr. 37 (3): 113–9. doi:10.1007/s10863-005-6222-3. PMID 16167168. 
  3. ^ Schwarz M, Andrade-Navarro MA, Gross A (May 2007). "Mitochondrial carriers and pores: key regulators of the mitochondrial apoptotic program?". Apoptosis 12 (5): 869–76. doi:10.1007/s10495-007-0748-2. PMID 17453157. 
  4. ^ Yu K, Ganesan K, Tan LK, Laban M, Wu J, Zhao XD, Li H, Leung CH, Zhu Y, Wei CL, Hooi SC, Miller L, Tan P (2008). Chang, Howard Y., ed. "A precisely regulated gene expression cassette potently modulates metastasis and survival in multiple solid cancers". PLoS Genet. 4 (7): e1000129. doi:10.1371/journal.pgen.1000129. PMC 2444049. PMID 18636107.  open access publication - free to read
  5. ^ Renström F, Payne F, Nordström A, et al. (April 2009). "Replication and extension of genome-wide association study results for obesity in 4923 adults from northern Sweden". Hum. Mol. Genet. 18 (8): 1489–96. doi:10.1093/hmg/ddp041. PMC 2664142. PMID 19164386. 

Further reading[edit]