MTCP1
From Wikipedia, the free encyclopedia
| Mature T-cell proliferation 1 | |||||||||||
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 PDB rendering based on 1a1x. |
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| Identifiers | |||||||||||
| Symbols | MTCP1; P13MTCP1; p8MTCP1 | ||||||||||
| External IDs | OMIM: 300116 MGI: 102699 HomoloGene: 82921 GeneCards: MTCP1 Gene | ||||||||||
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| RNA expression pattern | |||||||||||
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| Orthologs | |||||||||||
| Species | Human | Mouse | |||||||||
| Entrez | 4515 | 17763 | |||||||||
| Ensembl | ENSG00000214827 | ENSMUSG00000031200 | |||||||||
| UniProt | P56278 | Q60945 | |||||||||
| RefSeq (mRNA) | NM_001018024 | NM_001039373 | |||||||||
| RefSeq (protein) | NP_001018024 | NP_001034462 | |||||||||
| Location (UCSC) | Chr X: 154.29 – 154.38 Mb |
Chr X: 71.66 – 71.67 Mb |
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| PubMed search | [1] | [2] | |||||||||
Protein p13 MTCP-1 is a protein that in humans is encoded by the MTCP1 gene.[1][2][3][4]
This gene was identified by involvement in some t(X;14) translocations associated with mature T-cell proliferations. The gene has two ORFs that encode two different proteins. The upstream ORF encodes a 13kDa protein that is a member of the TCL1 family; this protein may be involved in leukemogenesis. The downstream ORF encodes an 8kDa protein that localizes to mitochondria. Alternative splicing results in multiple transcript variants.[4]
[edit] Interactions
MTCP1 has been shown to interact with AKT1.[5][6]
[edit] References
- ^ Stern MH, Soulier J, Rosenzwajg M, Nakahara K, Canki-Klain N, Aurias A, Sigaux F, Kirsch IR (Sep 1993). "MTCP-1: a novel gene on the human chromosome Xq28 translocated to the T cell receptor alpha/delta locus in mature T cell proliferations". Oncogene 8 (9): 2475–83. PMID 8361760.
- ^ Madani A, Choukroun V, Soulier J, Cacheux V, Claisse JF, Valensi F, Daliphard S, Cazin B, Levy V, Leblond V, Daniel MT, Sigaux F, Stern MH (Jul 1996). "Expression of p13MTCP1 is restricted to mature T-cell proliferations with t(X;14) translocations". Blood 87 (5): 1923–7. PMID 8634440.
- ^ Yang YS, Guignard L, Padilla A, Hoh F, Strub MP, Stern MH, Lhoste JM, Roumestand C (Sep 1998). "Solution structure of the recombinant human oncoprotein p13MTCP1". J Biomol NMR 11 (3): 337–54. doi:10.1023/A:1008279616063. PMID 9691281.
- ^ a b "Entrez Gene: MTCP1 mature T-cell proliferation 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4515.
- ^ Laine, Jarmo; Künstle Gerald, Obata Toshiyuki, Noguchi Masayuki (Feb. 2002). "Differential regulation of Akt kinase isoforms by the members of the TCL1 oncogene family". J. Biol. Chem. (United States) 277 (5): 3743–51. doi:10.1074/jbc.M107069200. ISSN 0021-9258. PMID 11707444.
- ^ Laine, J; Künstle G, Obata T, Sha M, Noguchi M (Aug. 2000). "The protooncogene TCL1 is an Akt kinase coactivator". Mol. Cell (UNITED STATES) 6 (2): 395–407. doi:10.1016/S1097-2765(00)00039-3. ISSN 1097-2765. PMID 10983986.
[edit] Further reading
- Kenwrick S, Levinson B, Taylor S, et al. (1993). "Isolation and sequence of two genes associated with a CpG island 5' of the factor VIII gene". Hum. Mol. Genet. 1 (3): 179–86. doi:10.1093/hmg/1.3.179. PMID 1303175.
- Madani A, Soulier J, Schmid M, et al. (1995). "The 8 kD product of the putative oncogene MTCP-1 is a mitochondrial protein". Oncogene 10 (11): 2259–62. PMID 7784073.
- Soulier J, Madani A, Cacheux V, et al. (1994). "The MTCP-1/c6.1B gene encodes for a cytoplasmic 8 kD protein overexpressed in T cell leukemia bearing a t(X;14) translocation". Oncogene 9 (12): 3565–70. PMID 7970717.
- Thick J, Mak YF, Metcalfe J, et al. (1994). "A gene on chromosome Xq28 associated with T-cell prolymphocytic leukemia in two patients with ataxia telangiectasia". Leukemia 8 (4): 564–73. PMID 8152252.
- Fisch P, Forster A, Sherrington PD, et al. (1993). "The chromosomal translocation t(X;14)(q28;q11) in T-cell pro-lymphocytic leukaemia breaks within one gene and activates another". Oncogene 8 (12): 3271–6. PMID 8247530.
- Gritti C, Choukroun V, Soulier J, et al. (1997). "Alternative origin of p13MTCP1-encoding transcripts in mature T-cell proliferations with t(X;14) translocations". Oncogene 15 (11): 1329–35. doi:10.1038/sj.onc.1201303. PMID 9315101.
- Barthe P, Yang YS, Chiche L, et al. (1998). "Solution structure of human p8MTCP1, a cysteine-rich protein encoded by the MTCP1 oncogene, reveals a new alpha-helical assembly motif". J. Mol. Biol. 274 (5): 801–15. doi:10.1006/jmbi.1997.1438. PMID 9405159.
- Du Bois GC, Song SP, Kulikovskaya I, et al. (1998). "Purification and characterization of recombinant forms of TCL-1 and MTCP-1 proteins". Protein Expr. Purif. 12 (2): 215–25. doi:10.1006/prep.1997.0822. PMID 9518463.
- Fu ZQ, Du Bois GC, Song SP, et al. (1998). "Crystal structure of MTCP-1: Implications for role of TCL-1 and MTCP-1 in T cell malignancies". Proc. Natl. Acad. Sci. U.S.A. 95 (7): 3413–8. doi:10.1073/pnas.95.7.3413. PMC 19850. PMID 9520380. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=19850.
- Guignard L, Padilla A, Mispelter J, et al. (2000). "Backbone dynamics and solution structure refinement of the 15N-labeled human oncogenic protein p13MTCP1: comparison with X-ray data". J. Biomol. NMR 17 (3): 215–30. doi:10.1023/A:1008386110930. PMID 10959629.
- Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=310948.
- Laine J, Künstle G, Obata T, Noguchi M (2002). "Differential regulation of Akt kinase isoforms by the members of the TCL1 oncogene family". J. Biol. Chem. 277 (5): 3743–51. doi:10.1074/jbc.M107069200. PMID 11707444.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
- Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528930.
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1347501.
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