MTRF1
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| Mitochondrial translational release factor 1 | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | MTRF1; MGC47721; MRF1; MTTRF1; RF1 | ||||||||||||
| External IDs | OMIM: 604601 MGI: 2384815 HomoloGene: 20903 GeneCards: MTRF1 Gene | ||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 9617 | 211253 | |||||||||||
| Ensembl | ENSG00000120662 | ENSMUSG00000022022 | |||||||||||
| UniProt | O75570 | Q8BJY8 | |||||||||||
| RefSeq (mRNA) | NM_004294 | NM_145960.4 | |||||||||||
| RefSeq (protein) | NP_004285 | NP_666072.3 | |||||||||||
| Location (UCSC) | Chr 13: 41.79 – 41.84 Mb |
Chr 14: 79.8 – 79.82 Mb |
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| PubMed search | [1] | [2] | |||||||||||
Mitochondrial translational release factor 1, also known as MTRF1 is a human gene.[1][2]
The protein encoded by this gene directs the termination of translation in response to the peptide chain termination codons. Initially thought to have a role in the termination of mitochondria protein synthesis.
[edit] References
- ^ Zhang Y, Spremulli LL (November 1998). "Identification and cloning of human mitochondrial translational release factor 1 and the ribosome recycling factor". Biochimica et Biophysica Acta 1443 (1-2): 245–50. doi:10.1016/S0167-4781(98)00223-1. PMID 9838146.
- ^ Hansen LL, Jørgensen R, Justesen J (2000). "Assignment of the human mitochondrial translational release factor 1 (MTRF1) to chromosome 13q14.1→q14.3 and of the human mitochondrial ribosome recycling factor (MRRF) to chromosome 9q32→q34.1 with radiation hybrid mapping". Cytogenetics and Cell Genetics 88 (1-2): 91–2. doi:10.1159/000015494. PMID 10773675.
[edit] Further reading
- Nozaki Y, Matsunaga N, Ishizawa T, et al. (2008). "HMRF1L is a human mitochondrial translation release factor involved in the decoding of the termination codons UAA and UAG.". Genes Cells 13 (5): 429–38. doi:10.1111/j.1365-2443.2008.01181.x. PMID 18429816.
- Dunham A, Matthews LH, Burton J, et al. (2004). "The DNA sequence and analysis of human chromosome 13.". Nature 428 (6982): 522–8. doi:10.1038/nature02379. PMC 2665288. PMID 15057823. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2665288.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Research 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nature Genetics 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proceedings of the National Academy of Sciences 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Soleimanpour-Lichaei HR, Kühl I, Gaisne M, et al. (2007). "mtRF1a is a human mitochondrial translation release factor decoding the major termination codons UAA and UAG.". Molecular Cell 27 (5): 745–57. doi:10.1016/j.molcel.2007.06.031. PMC 1976341. PMID 17803939. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1976341.
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