MUC3A

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Mucin 3A, cell surface associated
Identifiers
Symbols MUC3A ; MUC-3A; MUC3
External IDs OMIM158371 HomoloGene133199 GeneCards: MUC3A Gene
Orthologs
Species Human Mouse
Entrez 4584 666339
Ensembl ENSG00000169894 ENSMUSG00000037390
UniProt Q02505 n/a
RefSeq (mRNA) XM_001725354 XM_001478962
RefSeq (protein) XP_001725406 XP_001479012
Location (UCSC) Chr 7:
100.55 – 100.61 Mb
Chr 5:
137.13 – 137.15 Mb
PubMed search [1] [2]

Mucin-3A is a protein that in humans is encoded by the MUC3A gene.[1][2][3]


References[edit]

  1. ^ Gum JR, Hicks JW, Swallow DM, Lagace RL, Byrd JC, Lamport DT, Siddiki B, Kim YS (Oct 1990). "Molecular cloning of cDNAs derived from a novel human intestinal mucin gene". Biochem Biophys Res Commun 171 (1): 407–15. doi:10.1016/0006-291X(90)91408-K. PMID 2393399. 
  2. ^ Pratt WS, Crawley S, Hicks J, Ho J, Nash M, Kim YS, Gum JR, Swallow DM (Oct 2000). "Multiple transcripts of MUC3: evidence for two genes, MUC3A and MUC3B". Biochem Biophys Res Commun 275 (3): 916–23. doi:10.1006/bbrc.2000.3406. PMID 10973822. 
  3. ^ "Entrez Gene: MUC3A mucin 3A, cell surface associated". 

Further reading[edit]

  • Fox MF, Lahbib F, Pratt W et al. (1993). "Regional localization of the intestinal mucin gene MUC3 to chromosome 7q22". Ann. Hum. Genet. 56 (Pt 4): 281–7. doi:10.1111/j.1469-1809.1992.tb01154.x. PMID 1362870. 
  • Gum JR, Ho JJ, Pratt WS et al. (1997). "MUC3 human intestinal mucin. Analysis of gene structure, the carboxyl terminus, and a novel upstream repetitive region". J. Biol. Chem. 272 (42): 26678–86. doi:10.1074/jbc.272.42.26678. PMID 9334251. 
  • <Please add first missing authors to populate metadata.> (1999). "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. doi:10.1101/gr.8.11.1097. PMID 9847074. 
  • Williams SJ, Munster DJ, Quin RJ et al. (1999). "The MUC3 gene encodes a transmembrane mucin and is alternatively spliced". Biochem. Biophys. Res. Commun. 261 (1): 83–9. doi:10.1006/bbrc.1999.1001. PMID 10405327. 
  • Kitamoto S, Norishige Y, Seiya Y et al. (2010). "Promoter hypomethylation contributes to the expression of MUC3A in cancer cells". Biochem. Biophys. Res. Commun. 397 (2): 333–339. doi:10.1016/j.bbrc.2010.05.124. PMID 20510874. 
  • Crawley SC, Gum JR, Hicks JW et al. (1999). "Genomic organization and structure of the 3' region of human MUC3: alternative splicing predicts membrane-bound and soluble forms of the mucin". Biochem. Biophys. Res. Commun. 263 (3): 728–36. doi:10.1006/bbrc.1999.1466. PMID 10512748. 
  • Kyo K, Muto T, Nagawa H et al. (2001). "Associations of distinct variants of the intestinal mucin gene MUC3A with ulcerative colitis and Crohn's disease". J. Hum. Genet. 46 (1): 5–20. doi:10.1007/s100380170118. PMID 11289722. 
  • Hillier LW, Fulton RS, Fulton LA et al. (2003). "The DNA sequence of human chromosome 7". Nature 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948. 
  • Gum JR, Hicks JW, Crawley SC et al. (2004). "Initiation of transcription of the MUC3A human intestinal mucin from a TATA-less promoter and comparison with the MUC3B amino terminus". J. Biol. Chem. 278 (49): 49600–9. doi:10.1074/jbc.M305769200. PMID 12958310. 
  • Leroy X, Gouyer V, Ballereau C et al. (2003). "Quantitative RT-PCR assay for MUC3 and VEGF mRNA in renal clear cell carcinoma: relationship with nuclear grade and prognosis". Urology 62 (4): 771–5. doi:10.1016/S0090-4295(03)00560-0. PMID 14550470.