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Mucin 5AC, oligomeric mucus/gel-forming
Symbols MUC5AC ; MUC5; TBM; leB
External IDs OMIM158373 HomoloGene137237 GeneCards: MUC5AC Gene
Species Human Mouse
Entrez 4586 17833
Ensembl ENSG00000215182 ENSMUSG00000037974
UniProt P98088 n/a
RefSeq (mRNA) NM_017511 NM_010844
RefSeq (protein) n/a NP_034974
Location (UCSC) Chr 11:
1.15 – 1.22 Mb
Chr 7:
141.79 – 141.82 Mb
PubMed search [1] [2]

Mucin 5AC (Muc5AC) is a protein that in humans is encoded by the MUC5AC gene.[1][2][3]

Clinical relevance[edit]

This gene has been linked to mucus hypersecretion in the pulmonary tracts and associated to chronic obstructive pulmonary disease (COPD).[4]


  1. ^ Guyonnet Duperat V, Audie JP, Debailleul V, Laine A, Buisine MP, Galiegue-Zouitina S, Pigny P, Degand P, Aubert JP, Porchet N (Feb 1995). "Characterization of the human mucin gene MUC5AC: a consensus cysteine-rich domain for 11p15 mucin genes?". Biochem J 305 (Pt 1): 211–9. PMC 1136451. PMID 7826332. 
  2. ^ van de Bovenkamp JH, Hau CM, Strous GJ, Buller HA, Dekker J, Einerhand AW (Jun 1998). "Molecular cloning of human gastric mucin MUC5AC reveals conserved cysteine-rich D-domains and a putative leucine zipper motif". Biochem Biophys Res Commun 245 (3): 853–9. doi:10.1006/bbrc.1998.8535. PMID 9588204. 
  3. ^ "Entrez Gene: MUC5AC mucin 5AC, oligomeric mucus/gel-forming". 
  4. ^ Wang G, Xu Z, Wang R, Al-Hijji M, Salit J, Strulovici-Barel Y, Tilley A, Mezey J, Crystal R (June 2012). "Genes associated with MUC5AC expression in small airway epithelium of human smokers and nonsmokers". BMC Med Genomics 5 (1): 21. doi:10.1186/1755-8794-5-21. PMC 3443416. PMID 22676183.