Interferon-induced GTP-binding protein Mx2 is a protein that in humans is encoded by the MX2gene.
The protein encoded by this gene has a nuclear and a cytoplasmic form and is a member of both the dynamin family and the family of large GTPases. The nuclear form is localized in a granular pattern in the heterochromatin region beneath the nuclear envelope. A nuclear localization signal (NLS) is present at the amino terminal end of the nuclear form but is lacking in the cytoplasmic form due to use of an alternate translation start codon. This protein is upregulated by interferon-alpha but does not contain the antiviral activity of a similar myxovirus resistance protein 1.
^Melen K, Keskinen P, Ronni T, Sareneva T, Lounatmaa K, Julkunen I (Nov 1996). "Human MxB protein, an interferon-alpha-inducible GTPase, contains a nuclear targeting signal and is localized in the heterochromatin region beneath the nuclear envelope". J Biol Chem271 (38): 23478–86. doi:10.1074/jbc.271.38.23478. PMID8798556.
Horisberger MA, Wathelet M, Szpirer J et al. (1988). "cDNA cloning and assignment to chromosome 21 of IFI-78K gene, the human equivalent of murine Mx gene". Somat. Cell Mol. Genet.14 (2): 123–31. doi:10.1007/BF01534397. PMID3162334.