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Myosin, heavy chain 1, skeletal muscle, adult
Protein MYH1 PDB 1m8q.png
PDB rendering based on 1m8q.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols MYH1 ; HEL71; MYHSA1; MYHa; MyHC-2X/D; MyHC-2x
External IDs OMIM160730 MGI1339711 HomoloGene133718 GeneCards: MYH1 Gene
RNA expression pattern
PBB GE MYH1 205951 at tn.png
More reference expression data
Species Human Mouse
Entrez 4619 17879
Ensembl ENSG00000109061 ENSMUSG00000056328
UniProt P12882 Q5SX40
RefSeq (mRNA) NM_005963 NM_030679
RefSeq (protein) NP_005954 NP_109604
Location (UCSC) Chr 17:
10.4 – 10.42 Mb
Chr 11:
67.2 – 67.22 Mb
PubMed search [1] [2]

Myosin-1 is a protein that in humans is encoded by the MYH1 gene.[1][2]

Myosin is a major contractile protein that converts chemical energy into mechanical energy through the hydrolysis of ATP. Myosin is a hexameric protein composed of a pair of myosin heavy chains (MYH) and two pairs of nonidentical light chains. Myosin heavy chains are encoded by a multigene family. In mammals, at least ten different myosin heavy chain (MYH) isoforms have been described from striated, smooth, and nonmuscle cells. These isoforms show expression that is spatially and temporally regulated during development.[2]


  1. ^ Leinwand LA, Saez L, McNally E, Nadal-Ginard B (Jul 1983). "Isolation and characterization of human myosin heavy chain genes". Proc Natl Acad Sci U S A 80 (12): 3716–20. doi:10.1073/pnas.80.12.3716. PMC 394121. PMID 6304733. 
  2. ^ a b "Entrez Gene: MYH1 myosin, heavy chain 1, skeletal muscle, adult". 

Further reading[edit]