MYH10

Myosin, heavy chain 10, non-muscle
Identifiers
Symbols	MYH10; MGC134913; MGC134914; NMMHCB
External IDs	OMIM: 160776 MGI: 1930780 HomoloGene: 55941 GeneCards: MYH10 Gene
Gene Ontology
Molecular function	• microfilament motor activity; • nucleotide binding; • actin binding; • protein binding; • calmodulin binding; • ATP binding; • ATP binding; • actin-dependent ATPase activity; • ADP binding; • actin filament binding;
Cellular component	• stress fiber; • cytoplasm; • spindle; • plasma membrane; • cell cortex; • myosin complex; • axon; • growth cone; • midbody; • neuromuscular junction; • cleavage furrow; • neuronal cell body; • dendritic spine;
Biological process	• cytokinesis after mitosis; • in utero embryonic development; • neuron migration; • plasma membrane repair; • exocytosis; • substrate-dependent cell migration, cell extension; • nuclear migration; • axon guidance; • brain development; • adult heart development; • cell proliferation; • regulation of cell shape; • fourth ventricle development; • lateral ventricle development; • third ventricle development; • cerebellar Purkinje cell layer development; • actin cytoskeleton organization; • actin filament-based movement; • neuron projection development; • neuromuscular process controlling balance; • cardiac myofibril assembly; • ventricular cardiac muscle cell development; • retina development in camera-type eye;
	Sources: Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs

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Myosin-10 is a protein that in humans is encoded by the MYH10 gene.^[1]^[2]

[edit] References

^ Simons M, Wang M, McBride OW, Kawamoto S, Yamakawa K, Gdula D, Adelstein RS, Weir L (Aug 1991). "Human nonmuscle myosin heavy chains are encoded by two genes located on different chromosomes". Circ Res 69 (2): 530–9. PMID 1860190.
^ "Entrez Gene: MYH10 myosin, heavy chain 10, non-muscle". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4628.

[edit] Further reading

Phillips CL, Yamakawa K, Adelstein RS (1996). "Cloning of the cDNA encoding human nonmuscle myosin heavy chain-B and analysis of human tissues with isoform-specific antibodies.". J. Muscle Res. Cell. Motil. 16 (4): 379–89. doi:10.1007/BF00114503. PMID 7499478.
Strand D, Unger S, Corvi R, et al. (1995). "A human homologue of the Drosophila tumour suppressor gene l(2)gl maps to 17p11.2-12 and codes for a cytoskeletal protein that associates with nonmuscle myosin II heavy chain.". Oncogene 11 (2): 291–301. PMID 7542763.
Maupin P, Phillips CL, Adelstein RS, Pollard TD (1995). "Differential localization of myosin-II isozymes in human cultured cells and blood cells.". J. Cell. Sci. 107 (11): 3077–90. PMID 7699007.
Itoh K, Adelstein RS (1995). "Neuronal cell expression of inserted isoforms of vertebrate nonmuscle myosin heavy chain II-B.". J. Biol. Chem. 270 (24): 14533–40. doi:10.1074/jbc.270.24.14533. PMID 7782316.
Aikawa M, Sivam PN, Kuro-o M, et al. (1993). "Human smooth muscle myosin heavy chain isoforms as molecular markers for vascular development and atherosclerosis.". Circ. Res. 73 (6): 1000–12. PMID 7916668.
Shoeman RL, Sachse C, Höner B, et al. (1993). "Cleavage of human and mouse cytoskeletal and sarcomeric proteins by human immunodeficiency virus type 1 protease. Actin, desmin, myosin, and tropomyosin". Am. J. Pathol. 142 (1): 221–30. PMC 1886840. PMID 8424456. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1886840.
Kawamoto S (1996). "Neuron-specific alternative splicing of nonmuscle myosin II heavy chain-B pre-mRNA requires a cis-acting intron sequence". J. Biol. Chem. 271 (30): 17613–6. doi:10.1074/jbc.271.30.17613. PMID 8663598.
Weir L, Chen D (1997). "Characterization of the nonmuscle myosin heavy chain IIB promoter: regulation by E2F". Gene Expr. 6 (1): 45–57. PMID 8931991.
Ford HL, Silver DL, Kachar B, et al. (1998). "Effect of Mts1 on the structure and activity of nonmuscle myosin II". Biochemistry 36 (51): 16321–7. doi:10.1021/bi971182l. PMID 9405067.
Lin VK, Wang D, Lee IL, et al. (2000). "Myosin heavy chain gene expression in normal and hyperplastic human prostate tissue". Prostate 44 (3): 193–203. doi:10.1002/1097-0045(20000801)44:3<193::AID-PROS3>3.0.CO;2-A. PMID 10906735.
Nguyen M, Breckenridge DG, Ducret A, Shore GC (2000). "Caspase-Resistant BAP31 Inhibits Fas-Mediated Apoptotic Membrane Fragmentation and Release of Cytochrome c from Mitochondria". Mol. Cell. Biol. 20 (18): 6731–40. doi:10.1128/MCB.20.18.6731-6740.2000. PMC 86192. PMID 10958671. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=86192.
Wei Q, Adelstein RS (2000). "Conditional Expression of a Truncated Fragment of Nonmuscle Myosin II-A Alters Cell Shape but Not Cytokinesis in HeLa Cells". Mol. Biol. Cell 11 (10): 3617–27. PMC 15019. PMID 11029059. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=15019.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Wang F, Kovacs M, Hu A, et al. (2003). "Kinetic mechanism of non-muscle myosin IIB: functional adaptations for tension generation and maintenance". J. Biol. Chem. 278 (30): 27439–48. doi:10.1074/jbc.M302510200. PMID 12704189.
Huang H, Paliouras M, Rambaldi I, et al. (2003). "Nonmuscle Myosin Promotes Cytoplasmic Localization of PBX". Mol. Cell. Biol. 23 (10): 3636–45. doi:10.1128/MCB.23.10.3636-3645.2003. PMC 164772. PMID 12724421. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=164772.
Trinczek B, Brajenovic M, Ebneth A, Drewes G (2004). "MARK4 is a novel microtubule-associated proteins/microtubule affinity-regulating kinase that binds to the cellular microtubule network and to centrosomes". J. Biol. Chem. 279 (7): 5915–23. doi:10.1074/jbc.M304528200. PMID 14594945.
Straight AF, Field CM, Mitchison TJ (2005). "Anillin Binds Nonmuscle Myosin II and Regulates the Contractile Ring". Mol. Biol. Cell 16 (1): 193–201. doi:10.1091/mbc.E04-08-0758. PMC 539163. PMID 15496454. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=539163.
Bastian P, Lang K, Niggemann B, et al. (2005). "Myosin regulation in the migration of tumor cells and leukocytes within a three-dimensional collagen matrix". Cell. Mol. Life Sci. 62 (1): 65–76. doi:10.1007/s00018-004-4391-6. PMID 15619008.
Nakasawa T, Takahashi M, Matsuzawa F, et al. (2005). "Critical regions for assembly of vertebrate nonmuscle myosin II". Biochemistry 44 (1): 174–83. doi:10.1021/bi048807h. PMID 15628858.

This article on a gene on chromosome 17 is a stub. You can help Wikipedia by expanding it.

[pmid1860190-0] Simons M, Wang M, McBride OW, Kawamoto S, Yamakawa K, Gdula D, Adelstein RS, Weir L (Aug 1991). "Human nonmuscle myosin heavy chains are encoded by two genes located on different chromosomes". Circ Res 69 (2): 530–9. PMID 1860190.

[entrez-1] "Entrez Gene: MYH10 myosin, heavy chain 10, non-muscle". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4628.

[1]

[2]

MYH10

[edit] References

[edit] Further reading

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