MYL2

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Myosin, light chain 2, regulatory, cardiac, slow
Identifiers
Symbols MYL2 ; CMH10; MLC2
External IDs OMIM160781 MGI97272 HomoloGene55462 GeneCards: MYL2 Gene
RNA expression pattern
PBB GE MYL2 209742 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 4633 17906
Ensembl ENSG00000111245 ENSMUSG00000013936
UniProt P10916 P51667
RefSeq (mRNA) NM_000432 NM_010861
RefSeq (protein) NP_000423 NP_034991
Location (UCSC) Chr 12:
111.35 – 111.36 Mb
Chr 5:
122.1 – 122.11 Mb
PubMed search [1] [2]

Myosin regulatory light chain 2, ventricular/cardiac muscle isoform is a protein that in humans is encoded by the MYL2 gene.[1][2]

MYL2 encodes the regulatory light chain associated with cardiac myosin beta (or slow) heavy chain. Ca+ triggers the phosphorylation of regulatory light chain that in turn triggers contraction. Mutations in MYL2 are associated with mid-left ventricular chamber type hypertrophic cardiomyopathy.[2]

References[edit]

  1. ^ Macera MJ, Szabo P, Wadgaonkar R, Siddiqui MA, Verma RS (Aug 1992). "Localization of the gene coding for ventricular myosin regulatory light chain (MYL2) to human chromosome 12q23-q24.3". Genomics 13 (3): 829–31. doi:10.1016/0888-7543(92)90161-K. PMID 1386340. 
  2. ^ a b "Entrez Gene: MYL2 myosin, light chain 2, regulatory, cardiac, slow". 

Further reading[edit]

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