From Wikipedia, the free encyclopedia
Jump to: navigation, search
Myosin regulatory light chain interacting protein
Available structures
PDB Ortholog search: PDBe, RCSB
External IDs OMIM610082 MGI2388271 HomoloGene8309 GeneCards: MYLIP Gene
EC number 6.3.2.-
RNA expression pattern
PBB GE MYLIP 220319 s at tn.png
More reference expression data
Species Human Mouse
Entrez 29116 218203
Ensembl ENSG00000007944 ENSMUSG00000038175
UniProt Q8WY64 Q8BM54
RefSeq (mRNA) NM_013262 NM_153789
RefSeq (protein) NP_037394 NP_722484
Location (UCSC) Chr 6:
16.13 – 16.15 Mb
Chr 13:
45.39 – 45.41 Mb
PubMed search [1] [2]

Myosin regulatory light chain interacting protein, also known as MYLIP, is a protein that in humans is encoded by the MYLIP gene.[1]

MYLIP is also known as IDOL "Inducible Degrader of the LDL receptor" based on its involvement in cholesterol regulation.[2][3] The expression of IDOL is induced by the sterol-ativated liver X receptor.


The ERM protein family members ezrin, radixin, and moesin are cytoskeletal effector proteins linking actin to membrane-bound proteins at the cell surface. Myosin regulatory light chain interacting protein (MYLIP) is a novel ERM-like protein that interacts with myosin regulatory light chain and inhibits neurite outgrowth.[1]


  1. ^ a b "Entrez Gene: MYLIP myosin regulatory light chain interacting protein". 
  2. ^ Zelcer N, Hong C, Boyadjian R, Tontonoz P (July 2009). "LXR regulates cholesterol uptake through Idol-dependent ubiquitination of the LDL receptor". Science 325 (5936): 100–4. doi:10.1126/science.1168974. PMC 2777523. PMID 19520913. 
  3. ^ Lindholm D, Bornhauser BC, Korhonen L (November 2009). "Mylip makes an Idol turn into regulation of LDL receptor". Cell. Mol. Life Sci. 66 (21): 3399–402. doi:10.1007/s00018-009-0127-y. PMID 19688294. 

Further reading[edit]