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Myosin light chain kinase
Protein MYLK PDB 2cqv.png
PDB rendering based on 2cqv.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols MYLK ; AAT7; KRP; MLCK; MLCK1; MLCK108; MLCK210; MSTP083; MYLK1; smMLCK
External IDs OMIM600922 MGI894806 HomoloGene14202 IUPHAR: 1552 ChEMBL: 2428 GeneCards: MYLK Gene
EC number
RNA expression pattern
PBB GE MYLK 202555 s at tn.png
More reference expression data
Species Human Mouse
Entrez 4638 107589
Ensembl ENSG00000065534 ENSMUSG00000022836
UniProt Q15746 B1B1A8
RefSeq (mRNA) NM_005965 NM_139300
RefSeq (protein) NP_444253 NP_647461
Location (UCSC) Chr 3:
123.33 – 123.6 Mb
Chr 16:
34.75 – 35 Mb
PubMed search [1] [2]

Myosin light chain kinase, smooth muscle also known as kinase-related protein (KRP) or telokin is an enzyme that in humans is encoded by the MYLK gene.[1]


This gene, a muscle member of the immunoglobulin gene superfamily, encodes myosin light chain kinase which is a calcium/calmodulin dependent enzyme. This kinase phosphorylates myosin regulatory light chains to facilitate myosin interaction with actin filaments to produce contractile activity. This gene encodes both smooth muscle and nonmuscle isoforms. In addition, using a separate promoter in an intron in the 3' region, it encodes telokin, a small protein identical in sequence to the C-terminus of myosin light chain kinase, that is independently expressed in smooth muscle and functions to stabilize unphosphorylated myosin filaments. A pseudogene is located on the p arm of chromosome 3. Four transcript variants that produce four isoforms of the calcium/calmodulin dependent enzyme have been identified as well as two transcripts that produce two isoforms of telokin. Additional variants have been identified but lack full length transcripts.[2]

See also[edit]


  1. ^ Potier MC, Chelot E, Pekarsky Y, Gardiner K, Rossier J, Turnell WG (Mar 1996). "The human myosin light chain kinase (MLCK) from hippocampus: cloning, sequencing, expression, and localization to 3qcen-q21". Genomics 29 (3): 562–70. doi:10.1006/geno.1995.9965. PMID 8575746. 
  2. ^ "Entrez Gene: MYLK myosin, light chain kinase". 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.