MYLK3

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Myosin light chain kinase 3
Identifiers
Symbols MYLK3 ; MLCK; MLCK2; caMLCK
External IDs OMIM612147 MGI2443063 HomoloGene35278 ChEMBL: 4627 GeneCards: MYLK3 Gene
EC number 2.7.11.18
Orthologs
Species Human Mouse
Entrez 91807 213435
Ensembl ENSG00000140795 ENSMUSG00000031698
UniProt Q32MK0 Q3UIZ8
RefSeq (mRNA) NM_182493 NM_175441
RefSeq (protein) NP_872299 NP_780650
Location (UCSC) Chr 16:
46.74 – 46.82 Mb
Chr 8:
85.32 – 85.39 Mb
PubMed search [1] [2]

Myosin light chain kinase 3 also known as MYLK3, is an enzyme which in humans is encoded by the MYLK3 gene.[1][2]

Function[edit]

Phosphorylation of cardiac myosin heavy chains (see MYH7B) and light chains (see MYL2) by a kinase, such as MYLK3, potentiates the force and rate of cross-bridge recruitment in cardiac myocytes.[3]

See also[edit]

References[edit]

  1. ^ "Entrez Gene: MLCK MLCK protein". 
  2. ^ Seguchi O, Takashima S, Yamazaki S, Asakura M, Asano Y, Shintani Y, Wakeno M, Minamino T, Kondo H, Furukawa H, Nakamaru K, Naito A, Takahashi T, Ohtsuka T, Kawakami K, Isomura T, Kitamura S, Tomoike H, Mochizuki N, Kitakaze M (October 2007). "A cardiac myosin light chain kinase regulates sarcomere assembly in the vertebrate heart". J. Clin. Invest. 117 (10): 2812–24. doi:10.1172/JCI30804. PMC 1978424. PMID 17885681. 
  3. ^ Chan JY, Takeda M, Briggs LE, Graham ML, Lu JT, Horikoshi N, Weinberg EO, Aoki H, Sato N, Chien KR, Kasahara H (March 2008). "Identification of cardiac-specific myosin light chain kinase". Circ. Res. 102 (5): 571–80. doi:10.1161/CIRCRESAHA.107.161687. PMC 2504503. PMID 18202317. 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.