MYLK4

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myosin light chain kinase family, member 4
2X4F.pdb.png
The Crystal Structure of the Human Myosin Light Chain Kinase Loc340156.[1]
Identifiers
Symbol MYLK4
Entrez 340156
HUGO 27972
RefSeq NM_001012418
UniProt Q86YV6
Other data
Locus Chr. 6 p25.2

Myosin light chain kinase 4 also known as MYLK4 is an enzyme which in humans is encoded by the MYLK2 gene.[2] MYLK4 is a member of the myosin light-chain kinase family of serine/threonine-specific protein kinases that phosphorylate the regulatory light chain of myosin II.[3]

This protein acts as an enzyme that catalyzes the following reaction: ATP + a protein -> ADP + a phosphoprotein. [4]

MYLK4 is also involved in protein amino acid phosphorylation meaning that it adds a phosphate group onto the molecule. [5]

Not very much is known about the specific functional characteristics of MLYK4, but it has recently been found that the gene may possibly have a role in having at least one driver mutation for cancer. [6] MYLK4 may also be involved in transferase activity, ATP binding, protein serine/threonine kinase activity, and also nucleotide binding. [7] Other names for MYLK4 are CaMLCK like; EG238564; MYLK4; Mylk4; Myosin light chain kinase family, member 4; SgK085; SGK085; Sgk085; Sugen kinase 85; Uncharacterized serine/threonine-protein kinase SgK085. [8] The “Sgk” in the Sgk085 name for MYLK4 stands for to serum- and glucocorticoid-inducible kinases. These are serine/threonine protein kinases (SGKs) whose transcription is kept in check by cell volume, corticoids, and serum. [9]

There are other known myosin light-chain kinase enzymes.

References[edit]

  1. ^ "RCSB Protein Data Bank - Structure Summary for 2X4F - The Crystal Structure of the Human Myosin Light Chain Kinase Loc340156.". 
  2. ^ Manning G, Whyte DB, Martinez R, Hunter T, Sudarsanam S (December 2002). "The protein kinase complement of the human genome". Science 298 (5600): 1912–34. doi:10.1126/science.1075762. PMID 12471243. 
  3. ^ Gao Y, Ye LH, Kishi H, Okagaki T, Samizo K, Nakamura A, Kohama K (June 2001). "Myosin light chain kinase as a multifunctional regulatory protein of smooth muscle contraction". IUBMB Life 51 (6): 337–44. doi:10.1080/152165401753366087. PMID 11758800. 
  4. ^ "MYLK4 - Protein (Function), MYLK4 - Protein (Function)". 
  5. ^ "www.phosphosite.org". 
  6. ^ "SGC | Human Myosin Light Chain Kinase Family Member 4 (LOC340156) PDB Code: 2X4F". 
  7. ^ "MYLK4 Gene - GeneCards | MYLK4 Protein | MYLK4 Antibody". 
  8. ^ "Sgk085 : Protein Overview : UCSD Molecule Pages". 
  9. ^ "Oxford Reference Online".