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Myosin IC
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols MYO1C ; MMI-beta; MMIb; NMI; myr2
External IDs OMIM606538 MGI106612 HomoloGene32046 GeneCards: MYO1C Gene
RNA expression pattern
PBB GE MYO1C 214656 x at tn.png
PBB GE MYO1C 32811 at tn.png
More reference expression data
Species Human Mouse
Entrez 4641 17913
Ensembl ENSG00000197879 ENSMUSG00000017774
UniProt O00159 Q9WTI7
RefSeq (mRNA) NM_001080779 NM_001080774
RefSeq (protein) NP_001074248 NP_001074243
Location (UCSC) Chr 17:
1.37 – 1.4 Mb
Chr 11:
75.65 – 75.67 Mb
PubMed search [1] [2]

Myosin-Ic is a protein that in humans is encoded by the MYO1C gene.[1][2]

This gene encodes a member of the unconventional myosin protein family, which are actin-based molecular motors. The protein is found in the cytoplasm, and one isoform with a unique N-terminus is also found in the nucleus. The nuclear isoform associates with RNA polymerase I and II and functions in transcription initiation. The mouse ortholog of this protein also functions in intracellular vesicle transport to the plasma membrane. Multiple transcript variants encoding different isoforms have been found for this gene. The related gene myosin IE has been referred to as myosin IC in the literature, but it is a distinct locus on chromosome 19.[2]


  1. ^ Crozet F, el Amraoui A, Blanchard S, Lenoir M, Ripoll C, Vago P, Hamel C, Fizames C, Levi-Acobas F, Depetris D, Mattei MG, Weil D, Pujol R, Petit C (Apr 1997). "Cloning of the genes encoding two murine and human cochlear unconventional type I myosins". Genomics 40 (2): 332–41. doi:10.1006/geno.1996.4526. PMID 9119401. 
  2. ^ a b "Entrez Gene: MYO1C myosin IC". 

Further reading[edit]