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Myomesin 1
Myomesin Domains MY9-MY11. PDB 2y23[1]
Available structures
PDB Ortholog search: PDBe, RCSB
External IDs OMIM603508 MGI1341430 HomoloGene31196 GeneCards: MYOM1 Gene
RNA expression pattern
PBB GE MYOM1 205610 at tn.png
More reference expression data
Species Human Mouse
Entrez 8736 17929
Ensembl ENSG00000101605 ENSMUSG00000024049
UniProt P52179 Q62234
RefSeq (mRNA) NM_003803 NM_001083934
RefSeq (protein) NP_003794 NP_001077403
Location (UCSC) Chr 18:
3.07 – 3.22 Mb
Chr 17:
71.02 – 71.13 Mb
PubMed search [1] [2]

Myomesin-1 is a protein that in humans is encoded by the MYOM1 gene.[2][3]

The giant protein titin, together with its associated proteins, interconnects the major structure of sarcomeres, the M bands and Z discs. The C-terminal end of the titin string extends into the M line, where it binds tightly to M-band constituents of apparent molecular masses of 190 kD (myomesin 1) and 165 kD (myomesin 2). This protein, myomesin 1, like myomesin 2, titin, and other myofibrillar proteins contains structural modules with strong homology to either fibronectin type III (motif I) or immunoglobulin C2 (motif II) domains. Myomesin 1 and myomesin 2 each have a unique N-terminal region followed by 12 modules of motif I or motif II, in the arrangement II-II-I-I-I-I-I-II-II-II-II-II. The two proteins share 50% sequence identity in this repeat-containing region. The head structure formed by these 2 proteins on one end of the titin string extends into the center of the M band. The integrating structure of the sarcomere arises from muscle-specific members of the superfamily of immunoglobulin-like proteins. Alternatively spliced transcript variants encoding different isoforms have been identified.[3]


  1. ^ Pinotsis, N.; Chatziefthimiou, S. D.; Berkemeier, F.; Beuron, F.; Mavridis, I. M.; Konarev, P. V.; Svergun, D. I.; Morris, E.; Rief, M.; Wilmanns, M. (2012). Petsko, Gregory A, ed. "Superhelical Architecture of the Myosin Filament-Linking Protein Myomesin with Unusual Elastic Properties". PLoS Biology 10 (2): e1001261. doi:10.1371/journal.pbio.1001261. PMC 3279516. PMID 22347812.  edit
  2. ^ Speel EJ, van der Ven PF, Albrechts JC, Ramaekers FC, Furst DO, Hopman AH (Jan 1999). "Assignment of the human gene for the sarcomeric M-band protein myomesin (MYOM1) to 18p11.31-p11.32". Genomics 54 (1): 184–6. doi:10.1006/geno.1998.5503. PMID 9806852. 
  3. ^ a b "Entrez Gene: MYOM1 myomesin 1 (skelemin) 185kDa". 

Further reading[edit]