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Symbols MYPN ; CMD1DD; CMH22; MYOP; RCM4
External IDs OMIM608517 MGI1916052 HomoloGene23778 GeneCards: MYPN Gene
Species Human Mouse
Entrez 84665 68802
Ensembl ENSG00000138347 ENSMUSG00000020067
UniProt Q86TC9 Q5DTJ9
RefSeq (mRNA) NM_001256267 NM_182992
RefSeq (protein) NP_001243196 NP_892037
Location (UCSC) Chr 10:
69.87 – 69.97 Mb
Chr 10:
63.12 – 63.2 Mb
PubMed search [1] [2]

Myopalladin is a protein that in humans is encoded by the MYPN gene.[1][2][3]

MYPN is a component of the sarcomere that tethers nebulin (MIM 161650) in skeletal muscle and nebulette (MIM 605491) in cardiac muscle to alpha-actinin (see ACTN2; MIM 102573) at the Z lines (Bang et al., 2001).[supplied by OMIM][3]


MYPN has been shown to interact with Actinin, alpha 2,[1] ANKRD23[4] and ANKRD1.[1][4]


  1. ^ a b c Bang ML, Mudry RE, McElhinny AS, Trombitas K, Geach AJ, Yamasaki R, Sorimachi H, Granzier H, Gregorio CC, Labeit S (Apr 2001). "Myopalladin, a Novel 145-Kilodalton Sarcomeric Protein with Multiple Roles in Z-Disc and I-Band Protein Assemblies". J Cell Biol 153 (2): 413–27. doi:10.1083/jcb.153.2.413. PMC 2169455. PMID 11309420. 
  2. ^ Ma K, Wang K (Dec 2002). "Interaction of nebulin SH3 domain with titin PEVK and myopalladin: implications for the signaling and assembly role of titin and nebulin". FEBS Lett 532 (3): 273–8. doi:10.1016/S0014-5793(02)03655-4. PMID 12482578. 
  3. ^ a b "Entrez Gene: MYPN myopalladin". 
  4. ^ a b Miller, Melanie K; Bang Marie-Louise; Witt Christian C; Labeit Dietmar; Trombitas Charles; Watanabe Kaori; Granzier Henk; McElhinny Abigail S; Gregorio Carol C; Labeit Siegfried (Nov 2003). "The muscle ankyrin repeat proteins: CARP, ankrd2/Arpp and DARP as a family of titin filament-based stress response molecules". J. Mol. Biol. (England) 333 (5): 951–64. doi:10.1016/j.jmb.2003.09.012. ISSN 0022-2836. PMID 14583192. 

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