MYST3

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K(lysine) acetyltransferase 6A
Protein MYST3 PDB 1m36.png
PDB rendering based on 1m36.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols KAT6A ; MOZ; MYST3; RUNXBP2; ZC2HC6A; ZNF220
External IDs OMIM601408 MGI2442415 HomoloGene4924 GeneCards: KAT6A Gene
EC number 2.3.1.48
RNA expression pattern
PBB GE MYST3 202423 at tn.png
PBB GE MYST3 216361 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 7994 244349
Ensembl ENSG00000083168 ENSMUSG00000031540
UniProt Q92794 G3X940
RefSeq (mRNA) NM_001099412 NM_001081149
RefSeq (protein) NP_001092882 NP_001074618
Location (UCSC) Chr 8:
41.79 – 41.91 Mb
Chr 8:
22.86 – 22.94 Mb
PubMed search [1] [2]

MYST histone acetyltransferase (monocytic leukemia) 3, also known as MYST3, is an enzyme that, in humans, is encoded by the MYST3 gene.[1][2]

Function[edit]

MYST3 contains two nuclear localization domains, a C2HC3 zinc finger and an acetyltransferase domain. This structure suggests that MYST3 functions as a chromatin-bound acetyltransferase.[2] MYST3 is important for proper development of hematopoietic stem cells.[3]

References[edit]

  1. ^ "Entrez Gene: MYST3 MYST histone acetyltransferase (monocytic leukemia) 3". 
  2. ^ a b Borrow J, Stanton VP, Andresen JM, Becher R, Behm FG, Chaganti RS, Civin CI, Disteche C, Dubé I, Frischauf AM, Horsman D, Mitelman F, Volinia S, Watmore AE, Housman DE (September 1996). "The translocation t(8;16)(p11;p13) of acute myeloid leukaemia fuses a putative acetyltransferase to the CREB-binding protein". Nat. Genet. 14 (1): 33–41. doi:10.1038/ng0996-33. PMID 8782817. 
  3. ^ Yang XJ, Ullah M (August 2007). "MOZ and MORF, two large MYSTic HATs in normal and cancer stem cells". Oncogene 26 (37): 5408–19. doi:10.1038/sj.onc.1210609. PMID 17694082. 

Further reading[edit]