Macedon is often known as the town from "Picnic at Hanging Rock", the 1975 mystery movie based on the novel of the same name.
Parts of the 2009 Nicolas Cage film "Knowing" was shot around Macedon, most notably the local petrol station which was renovated to appear more like an American gas station. Most of the film was also shot nearby in Mount Macedon. The television series 'Chris Humfrey's Wild Life' was filmed in Macedon. The series aired in March 2011 on the 'Australian Broadcasting Corporation'